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List of works by Olga Lavrik

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Human replication protein A unfolds telomeric G-quadruplexes

scientific journal article
Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro.

scientific article published on 28 July 2016
The mechanism of human tyrosyl-DNA phosphodiesterase 1 in the cleavage of AP site and its synthetic analogs.

scientific article published on 31 October 2013
Binding polarity of RPA to telomeric sequences and influence of G-quadruplex stability

scientific journal article
Evidence for direct contact between the RPA3 subunit of the human replication protein A and single-stranded DNA

scientific article
Trapping of DNA topoisomerase I on nick-containing DNA in cell free extracts of Saccharomyces cerevisiae

scientific article published on 19 May 2006
Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety

scientific article published on 12 March 2015
Poly(ADP-ribose) polymerase 1 regulates activity of DNA polymerase beta in long patch base excision repair

scientific article published on 22 August 2009
Trapping of human DNA topoisomerase I by DNA structures mimicking intermediates of DNA repair

scientific article published on 01 February 2008
5' to 3' Unfolding Directionality of DNA Secondary Structures by Replication Protein A: G-QUADRUPLEXES AND DUPLEXES

scientific article
New inhibitors of tyrosyl-DNA phosphodiesterase I (Tdp 1) combining 7-hydroxycoumarin and monoterpenoid moieties

scientific article published on 13 September 2016
Coordinated regulation of replication protein A activities by its subunits p14 and p32.

scientific article published on 17 June 2004
Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin.

scientific article published on 14 November 2016
Essential functions of the 32 kDa subunit of yeast replication protein A.

scientific article published on 25 February 2009
Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy

scientific article published on 01 December 2018
Naked mole rat cells display more efficient excision repair than mouse cells

scientific article published on 01 June 2018
New synthetic substrates of mammalian nucleotide excision repair system

scientific article published on April 22, 2013
Prokaryotic and eukaryotic tetrameric phenylalanyl-tRNA synthetases display conservation of the binding mode of the tRNA(Phe) CCA end.

scientific article
p21CDKN1A Regulates the Binding of Poly(ADP-Ribose) Polymerase-1 to DNA Repair Intermediates

scientific article published on 5 January 2016
Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors

scientific article published on 24 July 2018
RPA and XPA interaction with DNA structures mimicking intermediates of the late stages in nucleotide excision repair

scientific article published on 10 January 2018
Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells

scientific article published on 20 August 2019
Dual DNA topoisomerase 1 and tyrosyl-DNA phosphodiesterase 1 inhibition for improved anticancer activity

scientific article published on 19 April 2019
Comprehensive analysis of telomerase inhibition by gallotannin

scientific article
Suppression of base excision repair reactions by apoptotic 24kDa-fragment of poly(ADP-ribose) polymerase 1 in bovine testis nuclear extract

scientific article published on 22 January 2007
Dual function of HPF1 in the modulation of PARP1 and PARP2 activities

scientific article published on 3 November 2021
Inhibitory Effect of New Semisynthetic Usnic Acid Derivatives on Human Tyrosyl-DNA Phosphodiesterase 1

scientific article published on 24 August 2018
Usnic Acid Conjugates with Monoterpenoids as Potent Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

scientific article published on 28 July 2020
Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors

scientific article published on 30 March 2021
DECIPHERING THE DARK SIDE OF HISTONE ADP-RIBOSYLATION: WHAT STRUCTURAL FEATURES OF DAMAGED NUCLEOSOME REGULATE THE ACTIVITIES OF PARP1 AND PARP2

New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2

scientific article published on 23 December 2021
New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1

scientific article published on 20 October 2021
Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Counts in Mice With Lewis Carcinoma by Tdp1 Inhibitors – New Usnic Acid Derivatives

Poly(ADP-ribose) in Condensates: The PARtnership of Phase Separation and Site-Specific Interactions

scientific article published on 15 November 2022
Journals in library science and bibliography: Multiaspect scientometric analysis

scientific article published in 2016
Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA

scientific article published on 24 September 2020
Photoreactive DNA as a Tool to Study Replication Protein A Functioning in DNA Replication and Repair

scientific article published on 03 February 2020
Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Counts in Mice with Lewis Carcinoma by Tdp1 Inhibitors—New Usnic Acid Derivatives

scientific article published on 19 January 2024
Non-canonical interaction of DNA repair proteins with intact and cleaved AP sites

scientific article published on 05 May 2020
Strand Displacement Activity of PrimPol

scientific article published on 27 November 2020
PARP1 Activation Controls Stress Granule Assembly after Oxidative Stress and DNA Damage

scientific article published on 5 December 2022
The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme

scientific article published on 28 September 2020
Sulfide, Sulfoxide, and Sulfone Derivatives of Usnic Acid as Inhibitors of Human TDP1 and TDP2 Enzymes

scientific article published on 17 December 2024
Influence of usnic acid and its derivatives on the activity of mammalian poly(ADP-ribose)polymerase 1 and DNA polymerase β.

scientific article
Biologically Relevant Polyamines, Divalent Metal Cations, and Structure of Poly(ADP-Ribose) All Control Microphase Separation of FUS with Poly(ADP-Ribosyl)ated PARP1

Nucleotide Excision Repair: From Molecular Defects to Neurological Abnormalities

scientific article published on 9 June 2021
Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1

scientific article published on 31 July 2020
Divalent and multivalent cations control liquid-like assembly of poly(ADP-ribosyl)ated PARP1 into multimolecular associates in vitro

scientific article published on 15 September 2024
Faculty Opinions recommendation of HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage.

Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor

scientific article published on 7 March 2023

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