List of works - Elizabeth Winzeler

Functional profiling of the Saccharomyces cerevisiae genome

scientific article (publication date: 25 July 2002)

A Genome-Wide Transcriptional Analysis of the Mitotic Cell Cycle

scientific article (publication date: July 1998)

Discovery of gene function by expression profiling of the malaria parasite life cycle

scientific article (publication date: 12 September 2003)

Replication dynamics of the yeast genome

scientific article published in October 2001

Spiroindolones, a potent compound class for the treatment of malaria

scientific article

Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle

scientific article

Genomic profiling of drug sensitivities via induced haploinsufficiency.

scientific article published on March 1999

Direct allelic variation scanning of the yeast genome

scientific article

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

scholarly article

Large-scale identification of single-feature polymorphisms in complex genomes

scientific article published on March 2003

Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae

scholarly article

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

scientific article (publication date: 9 December 2011)

The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification

scientific article published on September 2005

A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes

scientific article (publication date: 14 May 2010)

Targeting Plasmodium PI(4)K to eliminate malaria

scientific article (publication date: 12 December 2013)

The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites

scientific article

Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes

scientific article

A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article (publication date: 18 June 2015)

A systematic map of genetic variation in Plasmodium falciparum

scientific article

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility

scientific article

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

scientific article

Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite

scientific article (publication date: 2 November 2007)

Antimalarial drug discovery - approaches and progress towards new medicines.

scientific article

Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin

scientific article

Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials

scientific article (publication date: 13 February 2013)

Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families

scientific article

The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands

scientific article

Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

scientific article published on July 2010

A Plasmodium gene family encoding Maurer's cleft membrane proteins: structural properties and expression profiling

scientific article (publication date: June 2004)

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

scientific article (publication date: July 2016)

Validation of isoleucine utilization targets in Plasmodium falciparum

scientific article (publication date: 25 January 2011)

Malaria research in the post-genomic era

scientific article published in Nature

Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites

scientific article

In silico discovery of transcription regulatory elements in Plasmodium falciparum.

scientific article

Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design

scientific article

malERA: An updated research agenda for malaria elimination and eradication

scientific article published on 30 November 2017

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

scientific article (publication date: 7 September 2016)

Evidence-based annotation of the malaria parasite's genome using comparative expression profiling

scientific article

A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquito

scientific article

The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast

scientific article

UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes

scientific article (publication date: 19 September 2016)

Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast

scientific article

Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes

scientific article

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

scientific article published in January 2018

Experimentally induced blood-stage Plasmodium vivax infection in healthy volunteers.

scientific article published on August 2013

High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission

scientific article

Application of High-Density Array-Based Signature-Tagged Mutagenesis To Discover Novel Yersinia Virulence-Associated Genes

scientific article published on December 1, 2001

In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins

scientific article

Imidazolopiperazines: hit to lead optimization of new antimalarial agents.

scientific article published on 23 June 2011

KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission

scientific article

List of works by Elizabeth Winzeler

Functional profiling of the Saccharomyces cerevisiae genome

A Genome-Wide Transcriptional Analysis of the Mitotic Cell Cycle

Discovery of gene function by expression profiling of the malaria parasite life cycle

Replication dynamics of the yeast genome

Spiroindolones, a potent compound class for the treatment of malaria

Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle

Genomic profiling of drug sensitivities via induced haploinsufficiency.

Direct allelic variation scanning of the yeast genome

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

Large-scale identification of single-feature polymorphisms in complex genomes

Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification

A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes

Targeting Plasmodium PI(4)K to eliminate malaria

The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites

Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes

A novel multiple-stage antimalarial agent that inhibits protein synthesis

A systematic map of genetic variation in Plasmodium falciparum

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite

Antimalarial drug discovery - approaches and progress towards new medicines.

Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin

Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials

Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families

The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands

Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

A Plasmodium gene family encoding Maurer's cleft membrane proteins: structural properties and expression profiling

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Validation of isoleucine utilization targets in Plasmodium falciparum

Malaria research in the post-genomic era

Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites

In silico discovery of transcription regulatory elements in Plasmodium falciparum.

Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design

malERA: An updated research agenda for malaria elimination and eradication

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

Evidence-based annotation of the malaria parasite's genome using comparative expression profiling

A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquito

The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast

UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes

Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast

Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

Experimentally induced blood-stage Plasmodium vivax infection in healthy volunteers.

High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission

Application of High-Density Array-Based Signature-Tagged Mutagenesis To Discover Novel Yersinia Virulence-Associated Genes

In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins

Imidazolopiperazines: hit to lead optimization of new antimalarial agents.

KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission