List of works - Gerald Hoefler

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

scientific article

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.

scientific article published on 21 August 2011

Increased neutrophil-lymphocyte ratio is a poor prognostic factor in patients with primary operable and inoperable pancreatic cancer.

scientific article published on 25 June 2013

Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

scientific article published in Science

KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program.

scientific article published on 18 September 2008

Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing.

scientific article published on 05 April 2013

Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase

scholarly article

A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis

scientific article

Translational regulation mechanisms of AP-1 proteins

scientific article published on 09 January 2009

Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58).

scientific article

Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing.

scientific article

miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms

scientific article published on March 19, 2012

Intramural and extramural vascular invasion in colorectal cancer: prognostic significance and quality of pathology reporting

scientific article

Validation of C-reactive protein levels as a prognostic indicator for survival in a large cohort of pancreatic cancer patients.

scientific article

miR-181a is associated with poor clinical outcome in patients with colorectal cancer treated with EGFR inhibitor

scientific article

The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling

scientific article published on 09 August 2007

Evaluation of high-resolution melting analysis as a diagnostic tool to detect the BRAF V600E mutation in colorectal tumors.

scientific article published on 12 February 2009

Peroxisomal fatty acid beta-oxidation in HepG2 cells

scientific article published on September 1991

Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids

scientific article

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis

scientific article

Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer.

scientific article published on 22 June 2016

Down-regulation of KRAS-interacting miRNA-143 predicts poor prognosis but not response to EGFR-targeted agents in colorectal cancer

scientific article

External validation of the derived neutrophil to lymphocyte ratio as a prognostic marker on a large cohort of pancreatic cancer patients

scientific article

MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patients

scientific article

Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.

scientific article published on 8 February 2013

Peroxisomal bifunctional protein deficiency revisited: resolution of its true enzymatic and molecular basis

scientific article published on January 1999

Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia

scientific article

Tumor Macroenvironment and Metabolism

scientific article published on March 1, 2014

Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia

article

Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling

scientific article published on December 6, 2012

A stress-induced early innate response causes multidrug tolerance in melanoma

scientific article published on 24 November 2014

Prognostic relevance of tumour-associated macrophages and von Willebrand factor-positive microvessels in colorectal cancer

scientific article

Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH)

scientific article

MiR-96-5p influences cellular growth and is associated with poor survival in colorectal cancer patients.

scientific article published on 25 September 2014

The lymphocyte to monocyte ratio in peripheral blood represents a novel prognostic marker in patients with pancreatic cancer

scientific article published on 01 February 2015

Deletion analysis of the p16 tumor suppressor gene in gastrointestinal mucosa-associated lymphoid tissue lymphomas

Common alterations in gene expression and increased proliferation in recurrent acute myeloid leukemia

article

Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.

scientific article

The role of triglyceride lipases in cancer associated cachexia.

scientific article published on 14 March 2013

Mutation analyses in 17 patients with deficiency in acid beta-galactosidase: three novel point mutations and high correlation of mutation W273L with Morquio disease type B.

scientific article published in August 2001

Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis.

scientific article published on 6 September 2016

miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5.

scientific article published on 22 May 2017

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting

scientific article published on 16 August 2018

Loss of RAF kinase inhibitor protein is a somatic event in the pathogenesis of therapy-related acute myeloid leukemias with C-RAF germline mutations.

scientific article published on 9 April 2009

Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy

scientific article published in June 2009

A TRPC3 Blocker, Ethyl-1-(4-(2,3,3-Trichloroacrylamide)Phenyl)-5-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate (Pyr3), Prevents Stent-Induced Arterial Remodeling

scientific article published on 25 September 2012

Erratum: A stress-induced early innate response causes multidrug tolerance in melanoma

article

Skeletal muscle damage and impaired regeneration due to LPL-mediated lipotoxicity.

scientific article

Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients

scientific article published on 3 April 2015

High resolution SNP array genomic profiling of peripheral T cell lymphomas, not otherwise specified, identifies a subgroup with chromosomal aberrations affecting the REL locus

scientific article

List of works by Gerald Hoefler

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.

Increased neutrophil-lymphocyte ratio is a poor prognostic factor in patients with primary operable and inoperable pancreatic cancer.

Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program.

Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing.

Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase

A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis

Translational regulation mechanisms of AP-1 proteins

Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58).

Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing.

miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms

Intramural and extramural vascular invasion in colorectal cancer: prognostic significance and quality of pathology reporting

Validation of C-reactive protein levels as a prognostic indicator for survival in a large cohort of pancreatic cancer patients.

miR-181a is associated with poor clinical outcome in patients with colorectal cancer treated with EGFR inhibitor

The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling

Evaluation of high-resolution melting analysis as a diagnostic tool to detect the BRAF V600E mutation in colorectal tumors.

Peroxisomal fatty acid beta-oxidation in HepG2 cells

Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis

Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer.

Down-regulation of KRAS-interacting miRNA-143 predicts poor prognosis but not response to EGFR-targeted agents in colorectal cancer

External validation of the derived neutrophil to lymphocyte ratio as a prognostic marker on a large cohort of pancreatic cancer patients

MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patients

Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.

Peroxisomal bifunctional protein deficiency revisited: resolution of its true enzymatic and molecular basis

Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia

Tumor Macroenvironment and Metabolism

Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia

Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling

A stress-induced early innate response causes multidrug tolerance in melanoma

Prognostic relevance of tumour-associated macrophages and von Willebrand factor-positive microvessels in colorectal cancer

Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH)

MiR-96-5p influences cellular growth and is associated with poor survival in colorectal cancer patients.

The lymphocyte to monocyte ratio in peripheral blood represents a novel prognostic marker in patients with pancreatic cancer

Deletion analysis of the p16 tumor suppressor gene in gastrointestinal mucosa-associated lymphoid tissue lymphomas

Common alterations in gene expression and increased proliferation in recurrent acute myeloid leukemia

Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.

The role of triglyceride lipases in cancer associated cachexia.

Mutation analyses in 17 patients with deficiency in acid beta-galactosidase: three novel point mutations and high correlation of mutation W273L with Morquio disease type B.

Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis.

miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5.

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting

Loss of RAF kinase inhibitor protein is a somatic event in the pathogenesis of therapy-related acute myeloid leukemias with C-RAF germline mutations.

Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy

A TRPC3 Blocker, Ethyl-1-(4-(2,3,3-Trichloroacrylamide)Phenyl)-5-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate (Pyr3), Prevents Stent-Induced Arterial Remodeling

Erratum: A stress-induced early innate response causes multidrug tolerance in melanoma

Skeletal muscle damage and impaired regeneration due to LPL-mediated lipotoxicity.

Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients

High resolution SNP array genomic profiling of peripheral T cell lymphomas, not otherwise specified, identifies a subgroup with chromosomal aberrations affecting the REL locus