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List of works by Lars Tönges

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Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article
Mechanisms of acute axonal degeneration in the optic nerve in vivo

scientific article
ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells

scientific article published on 5 December 2007
Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease

scientific article
The spinal muscular atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin

scientific article published on 14 September 2011
ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS.

scientific article
Transduction of neural precursor cells with TAT-heat shock protein 70 chaperone: therapeutic potential against ischemic stroke after intrastriatal and systemic transplantation

scientific article published on June 2012
Axonal degeneration as a therapeutic target in the CNS.

scientific article published on 06 March 2012
ROCKing Regeneration: Rho Kinase Inhibition as Molecular Target for Neurorestoration.

scientific article
TAT-Hsp70-mediated neuroprotection and increased survival of neuronal precursor cells after focal cerebral ischemia in mice

scientific article published on 22 April 2009
Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis.

scientific article published on 6 December 2013
Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons.

scientific article
BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity.

scientific article published on 29 August 2008
GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice

scientific article published on 25 March 2015
Stearylated octaarginine and artificial virus-like particles for transfection of siRNA into primary rat neurons

scientific article published on 12 May 2006
Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease.

scientific article published on 24 December 2007
TGF-beta 1 enhances neurite outgrowth via regulation of proteasome function and EFABP.

scientific article published on 6 March 2010
AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo

scientific article published on 2 October 2014
Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo.

scientific article published on 26 April 2011
Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease

scientific article published on 22 April 2016
Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells

scientific article published on 25 September 2009
Upregulation of reggie-1/flotillin-2 promotes axon regeneration in the rat optic nerve in vivo and neurite growth in vitro

scientific article
Viral vector-mediated downregulation of RhoA increases survival and axonal regeneration of retinal ganglion cells

scientific article
JNK isoforms differentially regulate neurite growth and regeneration in dopaminergic neurons in vitro.

scientific article
ROCK inhibition in models of neurodegeneration and its potential for clinical translation

scientific article published on 2 April 2018
Classification of advanced stages of Parkinson's disease: translation into stratified treatments

scientific article published on 24 March 2017
Imaging of rat optic nerve axons in vivo

scientific article
Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease

scientific article published in August 2014
Hematopoietic cytokines--on the verge of conquering neurology

scientific article published on March 2007
Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration

scientific article
Modulation of Microglial Activity by Rho-Kinase (ROCK) Inhibition as Therapeutic Strategy in Parkinson's Disease and Amyotrophic Lateral Sclerosis

scientific article published on 04 April 2017
Alpha-synuclein mutations impair axonal regeneration in models of Parkinson's disease.

scientific article published on 10 September 2014
Acute axonal degeneration in vivo is attenuated by inhibition of autophagy in a calcium-dependent manner

scientific article published on July 2010
Clinical testing and spinal cord removal in a mouse model for amyotrophic lateral sclerosis (ALS)

scientific article published on 17 March 2012
Altered Expression of Growth Associated Protein-43 and Rho Kinase in Human Patients with Parkinson's Disease

scientific article published on 8 January 2016
Emerging Immunotherapies for Parkinson Disease

scientific article
The rho kinase inhibitor Y-27632 improves motor performance in male SOD1(G93A) mice

scientific article
Elemental fingerprint as a cerebrospinal fluid biomarker for the diagnosis of Parkinson's disease

scientific article published in February 2018
Coronal Transcranial Sonography and M-Mode Tremor Frequency Determination in Parkinson's Disease and Essential Tremor

scientific article published on 20 April 2017
Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation

scientific article published on 16 June 2017
Rho Kinase Inhibition with Fasudil in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis-Symptomatic Treatment Potential after Disease Onset

scientific article published on 31 January 2017
Novel Immunotherapeutic Approaches to Target Alpha-Synuclein and Related Neuroinflammation in Parkinson's Disease

scientific article published on 31 January 2019
Brainstem Raphe Alterations in TCS: A Biomarker for Depression and Apathy in Parkinson's Disease Patients

scholarly article by Daniel Richter et al published 2018 in Frontiers in Neurology
Parkinson-Erkrankung und Neuroinflammation – Zelluläre Pathologie, Mechanismen und therapeutische Optionen

scholarly article by Lars Tönges et al published 17 July 2018 in Fortschritte der Neurologie, Psychiatrie
Dynamics of Parkinson's Disease Multimodal Complex Treatment in Germany from 2010⁻2016: Patient Characteristics, Access to Treatment, and Formation of Regional Centers

article
miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons.

scientific article
Charakteristika und Dynamik der stationären Behandlung von Parkinson-Patienten in Deutschland

scholarly article by Lars Tönges et al published 6 August 2018 in Der Nervenarzt
Epidemiology of Parkinson's Disease and Current Concepts of Outpatient Care in Germany

scientific article published on 23 June 2017
Impairment of Motor Function Correlates with Neurometabolite and Brain Iron Alterations in Parkinson's Disease

scholarly article by Beate Pesch et al published 29 January 2019 in Cells
Praktische Anwendung der kontinuierlichen Apomorphin-Pumpentherapie

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