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List of works by Heinrich Kovar

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Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

scientific article
MIC2 is a specific marker for ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberrati

article
EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

scholarly article
Ewing's sarcoma family of tumors: current management

scientific article (publication date: May 2006)
Ewing Sarcoma: Current Management and Future Approaches Through Collaboration

scientific article published on 24 August 2015
Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients?

scientific article published in April 1996
A molecular function map of Ewing's sarcoma

scientific article published on 30 April 2009
Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II.

scientific article published on August 1998
Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors.

scientific article published on October 1997
EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma

scientific article
Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.

scientific article
Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial

scientific article published on 22 March 2010
Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma

scientific article (publication date: 12 February 2012)
Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells.

scientific article published on October 2006
Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours.

scientific article published in October 1993
Redirecting T cells to Ewing's sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection

scientific article
EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma

scientific article published on September 2008
Ewing sarcoma

scientific article published in July 2018
Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma

scientific article published on January 10, 2011
Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer

scientific article published on 12 August 2013
Context matters: the hen or egg problem in Ewing's sarcoma.

scientific article
CD133 expression in chemo-resistant Ewing sarcoma cells

scientific article
Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing's sarcoma cells in vitro

scientific article
Co-amplification of a novel gene, NAG, with the N-myc gene in neuroblastoma.

scientific article published in January 1999
Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family

scientific article published on December 9, 2010
Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma

scientific article published on 13 January 2012
DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.

scientific article
Neuroblastoma cells can actively eliminate supernumerary MYCN gene copies by micronucleus formation--sign of tumour cell revertance?

scientific article published on October 1997
Predictive potential of testing for bone marrow involvement in Ewing tumor patients by RT-PCR: a preliminary evaluation

scientific article published in February 1998
Downstream EWS/FLI1 - upstream Ewing's sarcoma

scientific article published on 28 January 2010
EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin

scientific article
Intercohort gene expression co-analysis reveals chemokine receptors as prognostic indicators in Ewing's sarcoma

scientific article
Detection of tumour cells in peripheral blood and bone marrow from Ewing tumour patients by RT-PCR.

scientific article published in April 1995
Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells.

scientific article published on 16 October 2012
Regression and progression in neuroblastoma. Does genetics predict tumour behaviour?

scientific article published in January 1995
Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy

scientific article published on August 27, 2014
Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein

scientific article published in October 2003
Intratumoural heterogeneity of 1p deletions and MYCN amplification in neuroblastomas

scientific article published in January 2001
Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma

scientific article published on 3 October 2014
Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing's sarcoma cells

scientific article published on 01 May 2006
O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing's sarcoma

scientific article published on 19 January 2009
Potentials for RNAi in sarcoma research and therapy: Ewing's sarcoma as a model.

scientific article published on August 2003
CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-κB signaling

scientific article published on 30 November 2015
Variability of nm23-H1/NDPK-A expression in human lymphomas and its relation to tumour aggressiveness

scientific article
An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B.

scientific article published on 18 July 2011
Overexpression of HOX genes is prevalent in Ewing sarcoma and is associated with altered epigenetic regulation of developmental transcription programs.

scientific article
Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene to a common tumor suppressor pathway

scientific article (publication date: 15 August 2002)
Fas- and activation-induced apoptosis are reduced in human T cells preactivated in the presence of TGF-beta 1.

scientific article published in January 1996
Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model

scientific article
The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease

scientific article

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