List of works - Carl R Walkley

IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα

scientific article published on 25 April 2016

Role of ADARs in mouse development

scientific article published in January 2012

Cell division and hematopoietic stem cells: not always exhausting

scientific article published on 7 July 2005

Murine models of osteosarcoma: A piece of the translational puzzle

scientific article published on 13 December 2017

Granulocyte colony-stimulating factor and an RARalpha specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cells

scientific article published on 01 February 2007

Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors

scientific article

Defining the hematopoietic stem cell niche: the chicken and the egg conundrum.

scientific article published on June 2011

Osteopenia in Siah1a mutant mice.

scientific article

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

scientific article published on 14 November 2017

Srsf2P95Hinitiates myeloid bias and myelodysplastic/myeloproliferative syndrome (MDS/MPN) from hemopoietic stem cells

article

Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during skeletal development

scientific article published on 10 September 2016

ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity

scientific article published on 25 October 2018

Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal

scientific article published on 06 November 2018

Darbepoietin-alfa has comparable erythropoietic stimulatory effects to recombinant erythropoietin whilst preserving the bone marrow microenvironment

scientific article published on 14 December 2012

Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure.

scientific article

PTHrP, its receptor, and protein kinase A activation in osteosarcoma

scientific article published on October 2014

Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53

scholarly article by Mannu K Walia et al published 28 August 2018 in Cell Death and Disease

The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation

scientific article

The majority of A-to-I RNA editing is not required for mammalian homeostasis

scientific article published on 09 December 2019

Small animal models for the study of bone sarcoma pathogenesis:characteristics, therapeutic interests and limitations

scientific article published on 21 February 2018

ATP-dependent helicase activity is dispensable for the physiological functions of Recql4

scientific article published on 05 July 2019

Taking HSCs down a Notch in leukemia.

scientific article published in June 2011

mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis

scientific article published in Scientific Reports

Gene expression profiling to define the cell intrinsic role of the SKI proto-oncogene in hematopoiesis and myeloid neoplasms

scientific article

Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia

scientific article published on 15 June 2020

The phenotype of the most common human ADAR1p150 Zα mutation P193A in mice is partially penetrant

scientific article published on 28 March 2023

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

scientific article published on 07 May 2019

Rothmund-Thomson Syndrome-like RECQL4 truncating mutations cause a haploinsufficient low bone mass phenotype in mice

scientific article published on 23 December 2020

Overexpression of ADAR1 in mice does not initiate or accelerate cancer formationin vivo

Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway

scientific article published on 04 December 2019

Srsf2P95H/+ co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia like disease in mice

Control of self-renewal and differentiation of hematopoietic stem cells by negative cell-cycle regulators

scientific article published on 01 April 2007

Srsf2P95H/+ co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia-like disease in mice

scientific article published on 21 October 2022

Murine Models of Bone Sarcomas

scientific article published on 01 January 2019

GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing

scientific article published on 22 November 2024

Defining the functions of adenosine-to-inosine RNA editing through hematology

scientific article published on 01 July 2019

Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replication

Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation

scientific article published on 30 March 2022

List of works by Carl R Walkley

IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα

Role of ADARs in mouse development

Cell division and hematopoietic stem cells: not always exhausting

Murine models of osteosarcoma: A piece of the translational puzzle

Granulocyte colony-stimulating factor and an RARalpha specific agonist, VTP195183, synergize to enhance the mobilization of hematopoietic progenitor cells

Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors

Defining the hematopoietic stem cell niche: the chicken and the egg conundrum.

Osteopenia in Siah1a mutant mice.

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

Srsf2P95Hinitiates myeloid bias and myelodysplastic/myeloproliferative syndrome (MDS/MPN) from hemopoietic stem cells

Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during skeletal development

ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity

Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal

Darbepoietin-alfa has comparable erythropoietic stimulatory effects to recombinant erythropoietin whilst preserving the bone marrow microenvironment

Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure.

PTHrP, its receptor, and protein kinase A activation in osteosarcoma

Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53

The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation

The majority of A-to-I RNA editing is not required for mammalian homeostasis

Small animal models for the study of bone sarcoma pathogenesis:characteristics, therapeutic interests and limitations

ATP-dependent helicase activity is dispensable for the physiological functions of Recql4

Taking HSCs down a Notch in leukemia.

mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis

Gene expression profiling to define the cell intrinsic role of the SKI proto-oncogene in hematopoiesis and myeloid neoplasms

Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia

The phenotype of the most common human ADAR1p150 Zα mutation P193A in mice is partially penetrant

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

Rothmund-Thomson Syndrome-like RECQL4 truncating mutations cause a haploinsufficient low bone mass phenotype in mice

Overexpression of ADAR1 in mice does not initiate or accelerate cancer formationin vivo

Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway

Srsf2P95H/+ co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia like disease in mice

Control of self-renewal and differentiation of hematopoietic stem cells by negative cell-cycle regulators

Srsf2P95H/+ co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia-like disease in mice

Murine Models of Bone Sarcomas

GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing

Defining the functions of adenosine-to-inosine RNA editing through hematology

Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replication

Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation

ADAR1p150 RNA binding, independent of A-to-I RNA editing, buffers immunogenicity from the tonic type I IFN induced transcriptome in vivo