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List of works by Valentina Zuco

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Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells

scientific article (publication date: 10 January 2002)
Targeting the Akt Kinase to Modulate Survival, Invasiveness and Drug Resistance of Cancer Cells

scientific article published on January 1, 2013
Cell cycle checkpoint efficiency and cellular response to paclitaxel in prostate cancer cells

scientific article
Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents.

scientific article published on 3 August 2017
miR-875-5p counteracts epithelial-to-mesenchymal transition and enhances radiation response in prostate cancer through repression of the EGFR-ZEB1 axis

scientific article published on 5 March 2017
The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition

scientific article published on 29 December 2009
Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo

scientific article (publication date: 2011)
Induction of apoptosis and stress response in ovarian carcinoma cell lines treated with ST1926, an atypical retinoid

scientific article published on March 2004
Subcellular localization of the camptothecin analogues, topotecan and gimatecan

scientific article published in March 2004
A novel atypical retinoid endowed with proapoptotic and antitumor activity

scientific article published in March 2003
Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors

scientific article
ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968.

scientific article
Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

scientific article published on 18 January 2017
Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine

scientific article published on 18 June 2010
Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis

scientific article published on June 2008
Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response.

scientific article
Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity

scientific article published on July 2005
Sensitization of tumor cells by targeting histone deacetylases

scientific article
The curative efficacy of namitecan (ST1968) in preclinical models of pediatric sarcoma is associated with antiangiogenic effects

scientific article
Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors

scientific article published on July 2010
Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors

scientific article published on 25 January 2011
Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.

scientific article
Development of resistance to the atypical retinoid, ST1926, in the lung carcinoma cell line H460 is associated with reduced formation of DNA strand breaks and a defective DNA damage response

scientific article published on July 2005
Efficacy of ST1968 (namitecan) on a topotecan-resistant squamous cell carcinoma

scientific article published on February 2010
Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

scientific article published on 19 September 2013
Targeting the invasive phenotype of cisplatin-resistant non-small cell lung cancer cells by a novel histone deacetylase inhibitor.

scientific article
miR-205 enhances radiation sensitivity of prostate cancer cells by impairing DNA damage repair through PKCε and ZEB1 inhibition

scientific article published on 04 February 2019
Isoxazolo(aza)naphthoquinones: a new class of cytotoxic Hsp90 inhibitors

scientific article published on 28 March 2012
Drug Combinations with Proteasome Inhibitors in Antitumor Therapy

scientific article published on January 1, 2013
A role for c-myc in DNA damage-induced apoptosis in a human TP53-mutant small-cell lung cancer cell line

scientific article
Antitumor activity of the combination of synthetic retinoid ST1926 and cisplatin in ovarian carcinoma models

scientific article published on 13 August 2007
Targeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer.

scientific article published on 16 June 2016
Modulation of cell sensitivity to antitumor agents by targeting survival pathways.

scientific article published on 3 August 2010
Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor, RC307: enhanced DNA damage response

scientific article published in March 2010
Intracellular accumulation and DNA damage persistence as determinants of human squamous cell carcinoma hypersensitivity to the novel camptothecin ST1968.

scientific article published on 27 April 2008
Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation

scientific article
Modulation of survival signaling pathways and persistence of the genotoxic stress as a basis for the synergistic interaction between the atypical retinoid ST1926 and the epidermal growth factor receptor inhibitor ZD1839.

scientific article
Patient-derived solitary fibrous tumour xenografts predict high sensitivity to doxorubicin/dacarbazine combination confirmed in the clinic and highlight the potential effectiveness of trabectedin or eribulin against this tumour.

scientific article published on 8 March 2017
Histone deacetylase and microtubules as targets for the synthesis of releasable conjugate compounds

scientific article published on 30 September 2009
Namitecan: a hydrophilic camptothecin with a promising preclinical profile

scientific article published on January 2012
Cellular bases of the antitumor activity of the novel taxane IDN 5109 (BAY59-8862) on hormone-refractory prostate cancer

scientific article published in August 2002
Role of c-myc protein in hormone refractory prostate carcinoma: cellular response to paclitaxel

scientific article
PLK1 is a critical determinant of tumor cell sensitivity to CPT11 and its inhibition enhances the drug antitumor efficacy in squamous cell carcinoma models sensitive and resistant to camptothecins.

scientific article published in April 2015
Exosome-like Nanovectors for Drug Delivery in Cancer

scientific article published on 01 January 2019
Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors

scientific article published on 5 September 2015
Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids

scientific article published on 3 May 2007
Synergistic antitumor activity of cetuximab and namitecan in human squamous cell carcinoma models relies on cooperative inhibition of EGFR expression and depends on high EGFR gene copy number

scientific article published on 10 December 2013
Targeting DNA topoisomerase I with non-camptothecin poisons.

scientific article published on January 2012
Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma.

scientific article published on 18 July 2016
UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53-replication protein A interaction in p53 wild type and mutant ovarian carcinoma cells

scientific article (publication date: December 2001)

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