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List of works by Jacob Giehm Mikkelsen

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IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication.

scientific article published on 23 October 2013
Transposition from a gutless adeno-transposon vector stabilizes transgene expression in vivo

scientific article published on 16 September 2002
Mutational analysis of the N-terminal DNA-binding domain of sleeping beauty transposase: critical residues for DNA binding and hyperactivity in mammalian cells

scientific article
Helper-Independent Sleeping Beauty transposon-transposase vectors for efficient nonviral gene delivery and persistent gene expression in vivo

scientific article published in October 2003
miRNA sponges: soaking up miRNAs for regulation of gene expression.

scientific article published on 23 December 2013
Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant

scientific article
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

scientific article
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.

scientific article published on 19 February 2016
Hybrid lentivirus-transposon vectors with a random integration profile in human cells.

scientific article
Induction of atherosclerosis in mice and hamsters without germline genetic engineering.

scientific article published on 27 March 2014
Functional IRF3 deficiency in a patient with herpes simplex encephalitis.

scientific article
Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cells

scientific article
Potent microRNA suppression by RNA Pol II-transcribed 'Tough Decoy' inhibitors

scientific article published on 18 December 2012
Amelioration of psoriasis by anti-TNF-alpha RNAi in the xenograft transplantation model

scientific article
Regulation of pro-inflammatory cytokines TNFα and IL24 by microRNA-203 in primary keratinocytes

scientific article published on 20 August 2012
Pig transgenesis by Sleeping Beauty DNA transposition

scientific article
Postintegrative gene silencing within the Sleeping Beauty transposition system

scientific article (publication date: December 2007)
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection

scientific article published on 16 June 2016
Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections

scientific article published on 07 August 2017
Managing microRNAs with vector-encoded decoy-type inhibitors

scientific article published on 11 June 2013
Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factors

scientific article published on 28 January 2015
Reduction of choroidal neovascularization in mice by adeno-associated virus-delivered anti-vascular endothelial growth factor short hairpin RNA.

scientific article
Targeted genome editing by lentiviral protein transduction of zinc-finger and TAL-effector nucleases

scientific article published on 24 April 2014
DNA transposon-based gene vehicles - scenes from an evolutionary drive

scientific article (publication date: 9 December 2013)
Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human β1 and α2 integrin

scientific article (publication date: 2012)
Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus

scientific article published on 9 June 2015
Suppression of microRNAs by dual-targeting and clustered Tough Decoy inhibitors

scientific article published on 16 January 2013
In Vivo Knockout of the Vegfa Gene by Lentiviral Delivery of CRISPR/Cas9 in Mouse Retinal Pigment Epithelium Cells.

scientific article published on 21 September 2017
Adeno-associated virus-delivered polycistronic microRNA-clusters for knockdown of vascular endothelial growth factor in vivo.

scientific article
DNA transposition by protein transduction of the piggyBac transposase from lentiviral Gag precursors

scientific article
High miR-34a expression improves response to doxorubicin in diffuse large B-cell lymphoma

scientific article published on 5 February 2016
Generation of minipigs with targeted transgene insertion by recombinase-mediated cassette exchange (RMCE) and somatic cell nuclear transfer (SCNT).

scientific article published on 31 October 2012
Cis-acting gene regulatory activities in the terminal regions of sleeping beauty DNA transposon-based vectors

scientific article published in December 2007
Efficient sleeping beauty DNA transposition from DNA minicircles

scientific article published on 26 February 2013
Targeting of human interleukin-12B by small hairpin RNAs in xenografted psoriatic skin

scientific article
Regulated gene insertion by steroid-induced PhiC31 integrase

scientific article published on 22 May 2008
Integrase-defective lentiviral vectors--a stage for nonviral integration machineries.

scientific article published on October 2011
The impact of cHS4 insulators on DNA transposon vector mobilization and silencing in retinal pigment epithelium cells

scientific article
Defective RNA sensing by RIG-I in severe influenza virus infection

scientific article published on 17 February 2018
Modulation of homo- and heterodimerization of Harvey sarcoma virus RNA by GACG tetraloops and point mutations in palindromic sequences

scientific article published in November 2002
Complementarity-directed RNA dimer-linkage promotes retroviral recombination in vivo

scientific article published on 9 January 2004
Suppression of Choroidal Neovascularization by AAV-Based Dual-Acting Antiangiogenic Gene Therapy

article
Dominant negative SERPING1 variants cause intracellular retention of C1-inhibitor in hereditary angioedema

scientific article published on 10 December 2018
Efficient replication of full-length murine leukemia viruses modified at the dimer initiation site regions

scientific article published on January 2004
Fv1-like restriction of N-tropic replication-competent murine leukaemia viruses in mCAT-1-expressing human cells

scientific article published on February 2002
Epigenetic marking and repression of porcine endogenous retroviruses

scientific article published on 16 January 2013
Human herpesvirus 6B U19 protein is a PML-regulated transcriptional activator that localizes to nuclear foci in a PML-independent manner

scientific article published on January 2008
U20 is responsible for human herpesvirus 6B inhibition of tumor necrosis factor receptor-dependent signaling and apoptosis

scientific article published on 15 August 2012
Targeted, homology-driven gene insertion in stem cells by ZFN-loaded 'all-in-one' lentiviral vectors.

scientific article published on 09 June 2016
A Sleeping Beauty DNA transposon-based genetic sensor for functional screening of vitamin D3 analogues

scientific article

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