List of works - Marco J Herold

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

scientific article published on 19 October 2016

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

scientific article published in December 2014

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

scientific article published on January 2012

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

scientific article

An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo

scientific article

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

scientific article

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

scientific article published on 17 November 2017

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

scientific article published on January 2014

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.

scientific article published on 14 July 2015

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

scientific article

Glucocorticoids exert opposing effects on macrophage function dependent on their concentration

scientific article published on 23 April 2007

Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways.

scientific article published on 11 December 2014

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1.

scientific article

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

scientific article published in August 2017

Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells

scientific article

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice

scientific article published on May 11, 2012

The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens

scientific article

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

scientific article published on January 2013

A1/Bfl-1 in leukocyte development and cell death

scientific article

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.

scientific article published on 13 January 2017

DNA repair processes are critical mediators of p53-dependent tumor suppression

scientific article published on 11 June 2018

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

scientific article

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

scientific article published on 31 March 2017

Targeting Mdmx to treat breast cancers with wild-type p53.

scientific article

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

scientific article

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

scientific article

Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells

scientific article published on 29 September 2017

Activation of the MAP kinase pathway induces apoptosis in the Merkel cell carcinoma cell line UISO.

scientific article published on 3 May 2007

The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.

scientific article published on 13 January 2017

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis

scientific article published on 14 April 2017

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

scientific article published on 23 August 2018

A non-canonical function of Ezh2 preserves immune homeostasis.

scientific article published on 21 February 2017

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

scientific article published on 24 April 2019

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice

scientific article published on 9 October 2014

CRISPR/Cas9-The ultimate weapon to battle infectious diseases?

scientific article

Hoxb8 regulates expression of microRNAs to control cell death and differentiation.

scientific article published on 19 July 2013

PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases.

scientific article

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

scientific article published on 11 December 2019

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

scientific article published on 18 February 2016

Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells.

scientific article published on 30 March 2017

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.

scientific article published in March 2018

Acid sphingomyelinase is required for protection of effector memory T cells against glucocorticoid-induced cell death

scientific article published on 23 September 2011

VDAC2 enables BAX to mediate apoptosis and limit tumor development

scientific article published in Nature Communications

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.

scientific article published on 20 January 2017

MDM4 is a rational target for treating breast cancers with mutant p53.

scientific article published on 18 January 2017

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.

scientific article published on 09 October 2015

Characterisation of a novel A1-specific monoclonal antibody.

scientific article published on 4 December 2014

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.

scientific article published on 30 September 2016

Proliferation arrest in B-Raf mutant melanoma cell lines upon MAPK pathway activation

scientific article

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice.

scientific article published on 12 September 2016

List of works by Marco J Herold

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway

An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

Glucocorticoids exert opposing effects on macrophage function dependent on their concentration

Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways.

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1.

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells

Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice

The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

A1/Bfl-1 in leukocyte development and cell death

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.

DNA repair processes are critical mediators of p53-dependent tumor suppression

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

Targeting Mdmx to treat breast cancers with wild-type p53.

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells

Activation of the MAP kinase pathway induces apoptosis in the Merkel cell carcinoma cell line UISO.

The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

A non-canonical function of Ezh2 preserves immune homeostasis.

BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice

CRISPR/Cas9-The ultimate weapon to battle infectious diseases?

Hoxb8 regulates expression of microRNAs to control cell death and differentiation.

PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases.

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells.

Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells.

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.

Acid sphingomyelinase is required for protection of effector memory T cells against glucocorticoid-induced cell death

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways.

MDM4 is a rational target for treating breast cancers with mutant p53.

Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.

Characterisation of a novel A1-specific monoclonal antibody.

Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM.

Proliferation arrest in B-Raf mutant melanoma cell lines upon MAPK pathway activation

RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice.