List of works - Patrick G. Kehoe

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

scientific article

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

scientific article (publication date: May 2011)

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease

scientific article

Abeta-degrading enzymes in Alzheimer's disease.

scientific article published on April 2008

Susceptibility locus for Alzheimer's disease on chromosome 10.

scientific article

A full genome scan for late onset Alzheimer's disease

scientific article published in February 1999

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

scientific article (publication date: 15 November 2010)

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease

article

Aβ-degrading enzymes: potential for treatment of Alzheimer disease.

scientific article

Full genome screen for Alzheimer disease: Stage II analysis

article

Drug repositioning for Alzheimer's disease.

scientific article

Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease

scientific article (publication date: 15 August 2005)

Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy

scientific article published in October 2006

Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias

scientific article published in January 2011

Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy

scientific article published on 31 October 2007

Haplotypes extending across ACE are associated with Alzheimer's disease

scientific article published in April 2003

Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism

scientific article published in April 2004

Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Abeta.

scientific article published on 18 June 2009

Distribution and Expression of Picalm in Alzheimer Disease

scientific article published on October 1, 2010

The cardiovascular and respiratory health of people with schizophrenia

scientific article published on April 2006

Genetic studies on chromosome 12 in late-onset Alzheimer disease

scientific article published in August 1998

Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity

scientific article published in August 2009

Therapeutic benefits from nanoparticles: the potential significance of nanoscience in diseases with compromise to the blood brain barrier

scientific article

Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease

scientific article

VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro.

scientific article published on 06 July 2013

Pathophysiology of white matter perfusion in Alzheimer's disease and vascular dementia

scientific article published on 10 March 2014

Changes with age in the activities of beta-secretase and the Abeta-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme

scientific article

Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue

scientific article published on 28 March 2014

Alpha-2 macroglobulin gene and Alzheimer disease

scientific article published in May 1999

CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease

scientific article

Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease

scientific article

Endothelin-1 is elevated in Alzheimer's disease and upregulated by amyloid-β.

scientific article

Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease

scientific article

Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment

scientific article published on 2 September 2016

Familial influence on variation in age of onset and behavioural phenotype in Alzheimer's disease.

scientific article published in February 2000

Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome

scientific article published on 30 November 2015

The Renin-Angiotensin System and Antihypertensive Drugs in Alzheimer's Disease: Current Standing of the Angiotensin Hypothesis?

scientific article published on January 1, 2012

The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

scientific article

The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease

scientific article

A cladistic model of ACE sequence variation with implications for myocardial infarction, Alzheimer disease and obesity

scientific article published on 14 September 2004

Oligomeric Abeta in Alzheimer's disease: relationship to plaque and tangle pathology, APOE genotype and cerebral amyloid angiopathy

scientific article published on 16 July 2009

The use of biomarkers for the etiologic diagnosis of MCI in Europe: an EADC survey

scientific article published on 20 August 2014

Higher soluble amyloid beta concentration in frontal cortex of young adults than in normal elderly or Alzheimer's disease

scientific article

Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease

scientific article published in October 2003

Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation.

scientific article

BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging

scientific article

Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project

scientific article

Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease

scientific article published on 23 August 2009

Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain

scientific article published in June 2005

List of works by Patrick G. Kehoe

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease

Abeta-degrading enzymes in Alzheimer's disease.

Susceptibility locus for Alzheimer's disease on chromosome 10.

A full genome scan for late onset Alzheimer's disease

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease

Aβ-degrading enzymes: potential for treatment of Alzheimer disease.

Full genome screen for Alzheimer disease: Stage II analysis

Drug repositioning for Alzheimer's disease.

Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease

Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy

Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias

Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy

Haplotypes extending across ACE are associated with Alzheimer's disease

Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism

Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Abeta.

Distribution and Expression of Picalm in Alzheimer Disease

The cardiovascular and respiratory health of people with schizophrenia

Genetic studies on chromosome 12 in late-onset Alzheimer disease

Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity

Therapeutic benefits from nanoparticles: the potential significance of nanoscience in diseases with compromise to the blood brain barrier

Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease

VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor A in vivo and in vitro.

Pathophysiology of white matter perfusion in Alzheimer's disease and vascular dementia

Changes with age in the activities of beta-secretase and the Abeta-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme

Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue

Alpha-2 macroglobulin gene and Alzheimer disease

CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease

Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease

Endothelin-1 is elevated in Alzheimer's disease and upregulated by amyloid-β.

Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease

Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment

Familial influence on variation in age of onset and behavioural phenotype in Alzheimer's disease.

Alzheimer's disease-like pathology has transient effects on the brain and blood metabolome

The Renin-Angiotensin System and Antihypertensive Drugs in Alzheimer's Disease: Current Standing of the Angiotensin Hypothesis?

The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease

A cladistic model of ACE sequence variation with implications for myocardial infarction, Alzheimer disease and obesity

Oligomeric Abeta in Alzheimer's disease: relationship to plaque and tangle pathology, APOE genotype and cerebral amyloid angiopathy

The use of biomarkers for the etiologic diagnosis of MCI in Europe: an EADC survey

Higher soluble amyloid beta concentration in frontal cortex of young adults than in normal elderly or Alzheimer's disease

Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease

Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation.

BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging

Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis Project

Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease

Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain