List of works - Gideon M. Hirschfield

C-reactive protein: a critical update

scientific article

C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease

scientific article

The gut microbiota and host health: a new clinical frontier

scientific article

Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants

scientific article

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

scientific article published on 16 October 2011

Targeting C-reactive protein for the treatment of cardiovascular disease.

scientific article

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

scientific article published in August 2016

Primary sclerosing cholangitis

scientific article published in The Lancet

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

scientific journal article

Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid.

scientific article

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

scientific article

Simeprevir increases rate of sustained virologic response among treatment-experienced patients with HCV genotype-1 infection: a phase IIb trial

scientific article published on November 2013

Overlap syndromes: the International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue

scientific article published on 18 September 2010

Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis

scientific article

The Immunobiology and Pathophysiology of Primary Biliary Cirrhosis

scientific article published on January 24, 2013

Pathogenesis of Cholestatic Liver Disease and Therapeutic Approaches

scientific article published on September 16, 2010

Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: an international follow-up study

scientific article published on 23 August 2014

Development and Validation of a Scoring System to Predict Outcomes of Patients With Primary Biliary Cirrhosis Receiving Ursodeoxycholic Acid Therapy.

scientific article published on 07 August 2015

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

scientific article

The evolution of cellular deficiency in GATA2 mutation

scientific article published on 17 December 2013

NOTCH2 mutations in Alagille syndrome

scientific article

Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice.

scientific article

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis

scientific article published on 5 March 2017

Daclatasvir plus peginterferon alfa and ribavirin for treatment-naive chronic hepatitis C genotype 1 or 4 infection: a randomised study

scientific article published on 30 July 2014

The UK-PBC risk scores: Derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cholangitis.

scientific article published on 29 July 2015

Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants

scientific article

Inflammation and endothelial function: direct vascular effects of human C-reactive protein on nitric oxide bioavailability

scientific article

PBC Screen: An IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis

scientific article published in December 2010

The Genetics of Complex Cholestatic Disorders

scientific article published on April 10, 2013

Novel therapeutic targets in primary biliary cirrhosis

scientific article

Transgenic human CRP is not pro-atherogenic, pro-atherothrombotic or pro-inflammatory in apoE-/- mice

scientific article

IgG4-related sclerosing disease: autoimmune pancreatitis and extrapancreatic manifestations

scientific article published on September 2011

Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study

scientific article

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

scientific article

Review article: overlap syndromes and autoimmune liver disease

scientific article published on 22 July 2012

Association of primary biliary cirrhosis with variants in the CLEC16A, SOCS1, SPIB and SIAE immunomodulatory genes.

scientific article published on 19 January 2012

The immunogenetics of primary biliary cirrhosis: A comprehensive review

scientific article

Using GWAS to identify genetic predisposition in hepatic autoimmunity

scientific article

Characterization of animal models for primary sclerosing cholangitis (PSC).

scientific article published on 19 February 2014

Surrogate endpoints for clinical trials in primary sclerosing cholangitis: Review and results from an International PSC Study Group consensus process

scientific article published on 29 September 2015

Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response.

scientific article

Prospective evaluation of ursodeoxycholic acid withdrawal in patients with primary sclerosing cholangitis

scientific article published on 30 July 2014

Progress in the genetics of primary biliary cirrhosis

scientific article published on 02 May 2011

Mechanisms of tissue injury in autoimmune liver diseases

scientific article published on August 2014

OX40, OX40L and Autoimmunity: a Comprehensive Review.

scientific article published on 28 July 2015

Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study.

scientific article published on 7 February 2017

CTLA4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population

scientific article published on April 2009

The gut-adherent microbiota of PSC-IBD is distinct to that of IBD.

scientific article

Seladelpar (MBX-8025), a selective PPAR-δ agonist, in patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid: a double-blind, randomised, placebo-controlled, phase 2, proof-of-concept study

scientific article

Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis

scientific article published on 12 April 2014

List of works by Gideon M. Hirschfield

C-reactive protein: a critical update

C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease

The gut microbiota and host health: a new clinical frontier

Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Targeting C-reactive protein for the treatment of cardiovascular disease.

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

Primary sclerosing cholangitis

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid.

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Simeprevir increases rate of sustained virologic response among treatment-experienced patients with HCV genotype-1 infection: a phase IIb trial

Overlap syndromes: the International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue

Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis

The Immunobiology and Pathophysiology of Primary Biliary Cirrhosis

Pathogenesis of Cholestatic Liver Disease and Therapeutic Approaches

Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: an international follow-up study

Development and Validation of a Scoring System to Predict Outcomes of Patients With Primary Biliary Cirrhosis Receiving Ursodeoxycholic Acid Therapy.

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

The evolution of cellular deficiency in GATA2 mutation

NOTCH2 mutations in Alagille syndrome

Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice.

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis

Daclatasvir plus peginterferon alfa and ribavirin for treatment-naive chronic hepatitis C genotype 1 or 4 infection: a randomised study

The UK-PBC risk scores: Derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cholangitis.

Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants

Inflammation and endothelial function: direct vascular effects of human C-reactive protein on nitric oxide bioavailability

PBC Screen: An IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis

The Genetics of Complex Cholestatic Disorders

Novel therapeutic targets in primary biliary cirrhosis

Transgenic human CRP is not pro-atherogenic, pro-atherothrombotic or pro-inflammatory in apoE-/- mice

IgG4-related sclerosing disease: autoimmune pancreatitis and extrapancreatic manifestations

Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

Review article: overlap syndromes and autoimmune liver disease

Association of primary biliary cirrhosis with variants in the CLEC16A, SOCS1, SPIB and SIAE immunomodulatory genes.

The immunogenetics of primary biliary cirrhosis: A comprehensive review

Using GWAS to identify genetic predisposition in hepatic autoimmunity

Characterization of animal models for primary sclerosing cholangitis (PSC).

Surrogate endpoints for clinical trials in primary sclerosing cholangitis: Review and results from an International PSC Study Group consensus process

Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response.

Prospective evaluation of ursodeoxycholic acid withdrawal in patients with primary sclerosing cholangitis

Progress in the genetics of primary biliary cirrhosis

Mechanisms of tissue injury in autoimmune liver diseases

OX40, OX40L and Autoimmunity: a Comprehensive Review.

Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study.

CTLA4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population

The gut-adherent microbiota of PSC-IBD is distinct to that of IBD.

Seladelpar (MBX-8025), a selective PPAR-δ agonist, in patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid: a double-blind, randomised, placebo-controlled, phase 2, proof-of-concept study

Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis