List of works - Aris Economides

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

scientific article (publication date: June 2003)

Bone morphogenetic proteins, their antagonists, and the skeleton

scientific article

Neural induction by the secreted polypeptide noggin

scientific article published in October 1993

The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities

scientific article

Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2

scientific article

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors.

scientific article

Structural basis of BMP signalling inhibition by the cystine knot protein Noggin

scientific article

Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy

scientific article

The BMP antagonist noggin regulates cranial suture fusion

scientific article

The mammalian gene function resource: the International Knockout Mouse Consortium

scientific article

Cytokine traps: multi-component, high-affinity blockers of cytokine action

scientific article (publication date: 2003)

RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity.

scientific article published on May 2015

ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.

scientific article

Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study

scientific article published on December 2016

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin

scientific article

Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients

scientific article (publication date: 18 January 2002)

Morphogenesis of digits in the avian limb is controlled by FGFs, TGFbetas, and noggin through BMP signaling

scientific article published on August 1998

Skeletal overexpression of gremlin impairs bone formation and causes osteopenia

scientific article

Skeletal Overexpression of Noggin Results in Osteopenia and Reduced Bone Formation

scientific article published on 01 May 2003

The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry

scientific article published on September 1999

Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone.

scientific article published in March 2004

Noncoding RNA transcription targets AID to divergently transcribed loci in B cells.

scientific article

Expression and function of Gdf-5 during digit skeletogenesis in the embryonic chick leg bud.

scientific article

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.

scientific article

Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways

scientific article

The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb

scientific article (published 1999-12-01)

Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism

scientific article published on September 2011

A lymphatic defect causes ocular hypertension and glaucoma in mice

scientific article (publication date: October 2014)

Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease

scientific article

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

scientific article

Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2.

scientific article published in May 2009

Identification of mammalian noggin and its expression in the adult nervous system

scientific article

Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis

scientific article

Conditional deletion of gremlin causes a transient increase in bone formation and bone mass

scientific article

The bone marrow microenvironment at single-cell resolution

scientific article published on 10 April 2019

Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.

scientific article published on November 2016

Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts

scientific article

In vivo somatic cell gene transfer of an engineered Noggin mutein prevents BMP4-induced heterotopic ossification

scientific article published in December 2003

The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow

scientific article published on 15 April 2011

Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome.

scientific article

BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b.

scientific article published on 10 November 2011

Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation

scientific article published on 20 February 2016

Follistatin and noggin are excluded from the zebrafish organizer.

scientific article published on December 1998

Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis

scientific article published on 23 December 2015

Podocyte-derived BMP7 is critical for nephron development

scientific article published on 15 October 2008

Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury

article

Conditionals by inversion provide a universal method for the generation of conditional alleles

scientific journal article

Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells

scientific article

Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding

scientific article

The Bone Morphogenetic Proteins Antagonist Noggin Inhibits Membranous Ossification

article

List of works by Aris Economides

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

Bone morphogenetic proteins, their antagonists, and the skeleton

Neural induction by the secreted polypeptide noggin

The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities

Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors.

Structural basis of BMP signalling inhibition by the cystine knot protein Noggin

Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy

The BMP antagonist noggin regulates cranial suture fusion

The mammalian gene function resource: the International Knockout Mouse Consortium

Cytokine traps: multi-component, high-affinity blockers of cytokine action

RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity.

ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.

Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin

Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients

Morphogenesis of digits in the avian limb is controlled by FGFs, TGFbetas, and noggin through BMP signaling

Skeletal overexpression of gremlin impairs bone formation and causes osteopenia

Skeletal Overexpression of Noggin Results in Osteopenia and Reduced Bone Formation

The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry

Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone.

Noncoding RNA transcription targets AID to divergently transcribed loci in B cells.

Expression and function of Gdf-5 during digit skeletogenesis in the embryonic chick leg bud.

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.

Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways

The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb

Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism

A lymphatic defect causes ocular hypertension and glaucoma in mice

Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2.

Identification of mammalian noggin and its expression in the adult nervous system

Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis

Conditional deletion of gremlin causes a transient increase in bone formation and bone mass

The bone marrow microenvironment at single-cell resolution

Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.

Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts

In vivo somatic cell gene transfer of an engineered Noggin mutein prevents BMP4-induced heterotopic ossification

The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow

Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome.

BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b.

Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation

Follistatin and noggin are excluded from the zebrafish organizer.

Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis

Podocyte-derived BMP7 is critical for nephron development

Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury

Conditionals by inversion provide a universal method for the generation of conditional alleles

Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells

Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding

The Bone Morphogenetic Proteins Antagonist Noggin Inhibits Membranous Ossification