List of works - Fredrik Karpe

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

scientific article

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

scientific article (publication date: November 2010)

Genetic studies of body mass index yield new insights for obesity biology

scientific article

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article

Common variants near MC4R are associated with fat mass, weight and risk of obesity

scientific article

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

scientific article published in June 2009

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Fatty acids, obesity, and insulin resistance: time for a reevaluation

scientific article

Gluteofemoral body fat as a determinant of metabolic health.

scientific article published on 12 January 2010

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

scientific article

Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages

scientific article published on 28 January 2008

Postprandial lipoproteins and progression of coronary atherosclerosis

scientific article published on 01 March 1994

Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma

scientific article published in April 2003

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

scientific article

Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)

Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation

scientific article published on 25 September 2014

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

scientific article

Postprandial lipoprotein metabolism and atherosclerosis.

scientific article

Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition?

scientific article

Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study

scientific article published on 22 February 2013

Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.

scientific article

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.

scientific article

Integrative physiology of human adipose tissue

scientific article published on 01 August 2003

Exome-wide association study of plasma lipids in >300,000 individuals

scientific article published on 30 October 2017

Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity

scientific article published on 19 March 2013

Biology of upper-body and lower-body adipose tissue--link to whole-body phenotypes.

scientific article

Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men.

scientific article published in August 1999

Effects of Recombinant Apolipoprotein A-I Milano on Aortic Atherosclerosis in Apolipoprotein E–Deficient Mice

scientific article published on March 3, 1998

PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

scientific article

Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period

scientific article published in January 2007

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

scientific article published on 12 September 2016

A genome-wide association search for type 2 diabetes genes in African Americans

scientific article published on 4 January 2012

Plasma tumour necrosis factor-alpha and early carotid atherosclerosis in healthy middle-aged men.

scientific article published in March 2002

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

scientific article published on February 2016

Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding

scientific article published in April 2008

Physical activity and exercise in the regulation of human adipose tissue physiology

scientific article published on January 2012

Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity

scientific article published in August 2002

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 22 December 2017

Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers

scientific article

Metabolism of triglyceride-rich lipoproteins during alimentary lipemia

scientific article published on March 1993

Transient triglyceridemia decreases vascular reactivity in young, healthy men without risk factors for coronary heart disease

scientific article published on 01 November 1997

Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man.

scientific article

Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage

scientific article published on 17 February 2009

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

scientific article published on 9 April 2018

The effects of APOE on the functional architecture of the resting brain

scientific article published on 7 August 2011

MicroRNAs in adipose tissue: their role in adipogenesis and obesity

scientific article published on 24 April 2012

List of works by Fredrik Karpe

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Genetic studies of body mass index yield new insights for obesity biology

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Common variants near MC4R are associated with fat mass, weight and risk of obesity

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

New genetic loci link adipose and insulin biology to body fat distribution

The genetic architecture of type 2 diabetes

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Fatty acids, obesity, and insulin resistance: time for a reevaluation

Gluteofemoral body fat as a determinant of metabolic health.

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages

Postprandial lipoproteins and progression of coronary atherosclerosis

Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

Rare and low-frequency coding variants alter human adult height

Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

Postprandial lipoprotein metabolism and atherosclerosis.

Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition?

Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study

Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.

Integrative physiology of human adipose tissue

Exome-wide association study of plasma lipids in >300,000 individuals

Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity

Biology of upper-body and lower-body adipose tissue--link to whole-body phenotypes.

Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men.

Effects of Recombinant Apolipoprotein A-I Milano on Aortic Atherosclerosis in Apolipoprotein E–Deficient Mice

PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

A genome-wide association search for type 2 diabetes genes in African Americans

Plasma tumour necrosis factor-alpha and early carotid atherosclerosis in healthy middle-aged men.

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding

Physical activity and exercise in the regulation of human adipose tissue physiology

Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers

Metabolism of triglyceride-rich lipoproteins during alimentary lipemia

Transient triglyceridemia decreases vascular reactivity in young, healthy men without risk factors for coronary heart disease

Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man.

Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

The effects of APOE on the functional architecture of the resting brain

MicroRNAs in adipose tissue: their role in adipogenesis and obesity