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List of works by Jan J. Brosens

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FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

scientific article (publication date: 12 December 2003)
Forkhead box proteins: tuning forks for transcriptional harmony.

scientific article published on July 2013
Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer

scientific article
Cyclic AMP and progesterone receptor cross-talk in human endometrium: a decidualizing affair.

scientific article
Cyclic decidualization of the human endometrium in reproductive health and failure.

scientific article
Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt.

scientific article published on January 2006
Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss

scientific article
FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism.

scientific article
Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells

scientific article published in March 2008
Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells

scientific article published on 3 July 2007
Cyclic AMP-induced forkhead transcription factor, FKHR, cooperates with CCAAT/enhancer-binding protein beta in differentiating human endometrial stromal cells

scientific article
FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer.

scientific article
Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization

scientific article
Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation

scientific article
Non-genomic progesterone actions in female reproduction.

scientific article published on 19 October 2008
The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression

scientific article published on 21 July 2008
The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium

scientific article
Progestins regulate the expression and activity of the forkhead transcription factor FOXO1 in differentiating human endometrium

scientific article published on 25 August 2005
Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium

scientific article published on 10 April 2017
Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure

scientific article
Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway

scientific article published on August 2009
Molecular aspects of implantation failure

scientific article
Mechanisms of endometrial progesterone resistance

scientific article
Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone

scientific article
Disordered IL-33/ST2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy loss

scientific article
SUMOylation inhibits FOXM1 activity and delays mitotic transition.

scientific article
Mechanism and functional consequences of loss of FOXO1 expression in endometrioid endometrial cancer cells.

scientific article
Uterine selection of human embryos at implantation

scientific article (publication date: 6 February 2014)
Composition, Development, and Function of Uterine Innate Lymphoid Cells

scientific article
The molecular basis of recurrent pregnancy loss: impaired natural embryo selection

scientific article published on 16 September 2010
Human homologs of the putative G protein-coupled membrane progestin receptors (mPRalpha, beta, and gamma) localize to the endoplasmic reticulum and are not activated by progesterone.

scientific article published on 7 September 2006
What exactly do we mean by 'recurrent implantation failure'? A systematic review and opinion.

scientific article
TBX22 missense mutations found in patients with X-linked cleft palate affect DNA binding, sumoylation, and transcriptional repression

scientific article
Regulated expression of putative membrane progestin receptor homologues in human endometrium and gestational tissues.

scientific article
Heparin prevents programmed cell death in human trophoblast

scientific article published on 23 March 2006
The human endometrium as a sensor of embryo quality

scientific article published on 03 September 2014
The role of FOXO1 in the decidual transformation of the endometrium and early pregnancy

scientific article published on 05 February 2013
Functional association of PR and CCAAT/enhancer-binding protein beta isoforms: promoter-dependent cooperation between PR-B and liver-enriched inhibitory protein, or liver-enriched activatory protein and PR-A in human endometrial stromal cells

scientific article published in January 2002
FOXO and FOXM1 in Cancer: The FOXO-FOXM1 Axis Shapes the Outcome of Cancer Chemotherapy

scientific article published on 01 August 2011
The diversity of sex steroid action: the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer

scientific article published on 07 March 2011
Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer

scientific article published on 30 December 2010
A role for uric acid and the Nalp3 inflammasome in antiphospholipid antibody-induced IL-1β production by human first trimester trophoblast.

scientific article
Progesterone acts via the nuclear glucocorticoid receptor to suppress IL-1β-induced COX-2 expression in human term myometrial cells

scientific article published in 2012
Modulation of trophoblast angiogenic factor secretion by antiphospholipid antibodies is not reversed by heparin

scientific article published on 4 May 2011
Impaired expression of endometrial differentiation markers and complement regulatory proteins in patients with recurrent pregnancy loss associated with antiphospholipid syndrome

scientific article
Sense and sensitivity: FOXO and ROS in cancer development and treatment

scientific article published on 20 October 2010
Role and Regulation of the Serum- and Glucocorticoid-Regulated Kinase 1 in Fertile and Infertile Human Endometrium

article
Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos

scientific article (publication date: 2012)
Loss of Endometrial Plasticity in Recurrent Pregnancy Loss.

scientific article published on 29 September 2015
Progesterone increases tissue factor gene expression, procoagulant activity, and invasion in the breast cancer cell line ZR-75-1.

scientific article

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