List of works - Andrew C Perkins

Stem cell transcriptome profiling via massive-scale mRNA sequencing

scientific article

Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation

scientific article

Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells

scientific article

A global role for EKLF in definitive and primitive erythropoiesis

scientific article

SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis

scientific article published on June 9, 1998

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells

scientific article published on 27 May 2010

Complex architecture and regulated expression of the Sox2ot locus during vertebrate development

scientific article

Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates.

scientific article published on 13 May 2009

Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis

scientific article

Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor

scientific article published in July 2003

In vitro differentiation of murine embryonic stem cells toward a renal lineage

scientific article published on 5 February 2007

Prediction of novel long non-coding RNAs based on RNA-Seq data of mouse Klf1 knockout study

scientific article

Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor

scientific article published on August 1996

Human KLF17 is a new member of the Sp/KLF family of transcription factors

scientific article published on 7 February 2006

High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22

scientific article published on 28 June 2016

Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells.

scientific article published on 5 February 2007

EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2.

scientific article published on 20 May 2009

Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-freeBMP4 culture

scientific article

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes.

scientific article published on 4 March 2014

Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.

scientific article

Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial

scientific article

KLF1 directly coordinates almost all aspects of terminal erythroid differentiation.

scientific article

A high-throughput screening strategy for detecting CRISPR-Cas9 induced mutations using next-generation sequencing

scientific article

Distinct domains of erythroid Krüppel-like factor modulate chromatin remodeling and transactivation at the endogenous beta-globin gene promoter

scientific article

Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants

scientific article

Three fingers on the switch: Krüppel-like factor 1 regulation of γ-globin to β-globin gene switching

scientific article published on May 2013

Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.

scientific article

Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis

scientific article

KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome.

scientific article

Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing

scientific article

Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos

scientific article published on 01 March 2000

A global role for zebrafish klf4 in embryonic erythropoiesis

scientific article published on 23 June 2007

Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor

scientific article

The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo

scientific article

neptune, a Krüppel-like transcription factor that participates in primitive erythropoiesis in Xenopus

scientific article published in September 2001

Megakaryocyte-erythroid lineage promiscuity in EKLF null mouse blood

scientific article published on 22 October 2009

Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain

scientific article

A recessive screen for genes regulating hematopoietic stem cells.

scientific article published on 7 July 2010

A mechanism for Ikaros regulation of human globin gene switching.

scientific article published on 3 March 2008

Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching

scientific article published in December 2005

Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development

scientific article published on 9 March 2006

Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation

scientific article published on 12 November 2007

Indian hedgehog supports definitive erythropoiesis

scientific article

The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.

scientific article

Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability

scientific article

Macrophages and regulation of erythropoiesis

scientific article

Erythroid Krüppel-like factor is essential for beta-globin gene expression even in absence of gene competition, but is not sufficient to induce the switch from gamma-globin to beta-globin gene expression.

scientific article published in April 1998

Using genome-wide associations to identify metabolic pathways involved in maize aflatoxin accumulation resistance

scientific article published on September 3, 2015

Genomic organisation and regulation of murine alpha haemoglobin stabilising protein by erythroid Kruppel-like factor

scientific article published on 27 October 2006

C/EBPdelta and C/EBPgamma bind the CCAAT-box in the human beta-globin promoter and modulate the activity of the CACC-box binding protein, EKLF

scientific article

List of works by Andrew C Perkins

Stem cell transcriptome profiling via massive-scale mRNA sequencing

Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation

Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells

A global role for EKLF in definitive and primitive erythropoiesis

SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells

Complex architecture and regulated expression of the Sox2ot locus during vertebrate development

Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates.

Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis

Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor

In vitro differentiation of murine embryonic stem cells toward a renal lineage

Prediction of novel long non-coding RNAs based on RNA-Seq data of mouse Klf1 knockout study

Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor

Human KLF17 is a new member of the Sp/KLF family of transcription factors

High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22

Erythroid Krüppel-like factor directly activates the basic Krüppel-like factor gene in erythroid cells.

EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2.

Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-freeBMP4 culture

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes.

Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.

Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial

KLF1 directly coordinates almost all aspects of terminal erythroid differentiation.

A high-throughput screening strategy for detecting CRISPR-Cas9 induced mutations using next-generation sequencing

Distinct domains of erythroid Krüppel-like factor modulate chromatin remodeling and transactivation at the endogenous beta-globin gene promoter

Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants

Three fingers on the switch: Krüppel-like factor 1 regulation of γ-globin to β-globin gene switching

Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.

Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis

KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome.

Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing

Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos

A global role for zebrafish klf4 in embryonic erythropoiesis

Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor

The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo

neptune, a Krüppel-like transcription factor that participates in primitive erythropoiesis in Xenopus

Megakaryocyte-erythroid lineage promiscuity in EKLF null mouse blood

Histone deacetylase-dependent establishment and maintenance of broad low-level histone acetylation within a tissue-specific chromatin domain

A recessive screen for genes regulating hematopoietic stem cells.

A mechanism for Ikaros regulation of human globin gene switching.

Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching

Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development

Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation

Indian hedgehog supports definitive erythropoiesis

The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development.

Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability

Macrophages and regulation of erythropoiesis

Erythroid Krüppel-like factor is essential for beta-globin gene expression even in absence of gene competition, but is not sufficient to induce the switch from gamma-globin to beta-globin gene expression.

Using genome-wide associations to identify metabolic pathways involved in maize aflatoxin accumulation resistance

Genomic organisation and regulation of murine alpha haemoglobin stabilising protein by erythroid Kruppel-like factor

C/EBPdelta and C/EBPgamma bind the CCAAT-box in the human beta-globin promoter and modulate the activity of the CACC-box binding protein, EKLF