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List of works by Kristen J. Brennand

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Modelling schizophrenia using human induced pluripotent stem cells

scientific article
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

scientific article
Gene expression elucidates functional impact of polygenic risk for schizophrenia

scientific article published on 26 September 2016
Mosaic copy number variation in human neurons

scientific article
Reprogramming of pancreatic beta cells into induced pluripotent stem cells

scientific article
Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia

scientific article
Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

scientific article published on 28 October 2015
All beta cells contribute equally to islet growth and maintenance

scientific article published on 29 May 2007
Modeling hippocampal neurogenesis using human pluripotent stem cells

scientific article published on 27 February 2014
A role for noncoding variation in schizophrenia

scientific article
Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises

scientific article published on 09 August 2011
Altered proliferation and networks in neural cells derived from idiopathic autistic individuals

scientific article published on 05 July 2016
Investigating synapse formation and function using human pluripotent stem cell-derived neurons

scientific article
Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics

scholarly article
Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons

scientific article
Modeling psychiatric disorders at the cellular and network levels

scientific article
Rapid cellular turnover in adipose tissue

scientific article
Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders.

scientific article
Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells

scientific article published on 21 April 2016
Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease

scientific article
Concise review: the promise of human induced pluripotent stem cell-based studies of schizophrenia

scientific article
Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

scientific article
Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines

scientific article published on July 2011
High-efficient generation of induced pluripotent stem cells from human astrocytes

scientific article (publication date: 9 December 2010)
Altered WNT Signaling in Human Induced Pluripotent Stem Cell Neural Progenitor Cells Derived from Four Schizophrenia Patients

scientific article published on 30 January 2015
Modeling heterogeneous patients with a clinical diagnosis of schizophrenia with induced pluripotent stem cells

scientific article
Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease

scientific article
Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains.

scientific article published on 20 December 2017
Modeling psychiatric disorders through reprogramming

scientific article published on 4 October 2011
Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells

scientific article published on 25 November 2015
Characterization of molecular and cellular phenotypes associated with a heterozygous CNTNAP2 deletion using patient-derived hiPSC neural cells.

scientific article published on June 2015
Spatial genome organization and cognition

scientific article
Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders

scientific article
Cerebral organoids reveal early cortical maldevelopment in schizophrenia—computational anatomy and genomics, role of FGFR1.

scientific article published on 17 November 2017
A guide to generating and using hiPSC derived NPCs for the study of neurological diseases

scientific article
Increased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients.

scientific article published on 20 October 2015
New considerations for hiPSC-based models of neuropsychiatric disorders

scientific article published on 26 February 2018
Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models.

scientific article
The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample

scientific article
Synergistic effects of common schizophrenia risk variants

scientific article published on 23 September 2019
Modeling schizophrenia using induced pluripotent stem cell-derived and fibroblast-induced neurons

scientific article published on 19 November 2012
Expression-based drug screening of neural progenitor cells from individuals with schizophrenia

scientific article published in Nature Communications
Slow and steady is the key to beta-cell replication

scientific article
Neural stem and progenitor cells in health and disease

scientific article published on 20 September 2013
From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric Disease

scientific article published on April 27, 2015
A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles

scientific article published on 09 March 2020
Neural organoids for disease phenotyping, drug screening and developmental biology studies

scientific article published on 12 October 2016
Dopaminergic differentiation of schizophrenia hiPSCs

scientific article published on 27 January 2015
Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder

scientific article published on 16 November 2018
Application of CRISPR/Cas9 to the study of brain development and neuropsychiatric disease

scientific article

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