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List of works by Nicholas McGranahan

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Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

scientific article published on 03 March 2016
The causes and consequences of genetic heterogeneity in cancer evolution

scientific article (publication date: 19 September 2013)
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

scientific article
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

scientific article
Tracking the Evolution of Non-Small-Cell Lung Cancer

scientific article published on 26 April 2017
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future

scientific article published on February 2017
Biological and therapeutic impact of intratumor heterogeneity in cancer evolution

scientific article
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

scientific article
DeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution

scientific article published on 22 February 2016
Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

scientific article
Cancer chromosomal instability: therapeutic and diagnostic challenges

scientific article
Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer

scientific article published on 12 April 2018
Chromosomal instability drives metastasis through a cytosolic DNA response

scientific article published on 17 January 2018
Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

scientific article published on October 26, 2017
Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis

scientific article published on 07 July 2017
APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity

scientific article published on 19 June 2015
Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.

scientific article
Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy

scientific article published on 23 May 2015
Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

scientific article published on 11 April 2018
Cancer: evolution within a lifetime

scientific article published on October 2014
Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine

scientific article
Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes.

scientific article published on 29 August 2016
Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal

scientific article published on 4 April 2018
Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers

scientific article published on 6 November 2017
Neoantigen-directed immune escape in lung cancer evolution

scientific article published on 20 March 2019
Tracking genomic cancer evolution for precision medicine: the lung TRACERx study

scientific article
SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

scientific article
Ultra-deep T cell receptor sequencing reveals the complexity and intratumour heterogeneity of T cell clones in renal cell carcinomas

scientific article
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer

scientific article
Parallel evolution of tumour subclones mimics diversity between tumours

scientific article published in August 2013
BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer

scientific article
APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability

scientific article published on 9 January 2017
Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution

scientific article
APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution

scientific article published on 8 January 2018
Consensus on precision medicine for metastatic cancers: a report from the MAP conference.

scientific article published on 3 May 2016
Inferring mutational timing and reconstructing tumour evolutionary histories

scientific article
Differential binding affinity of mutated peptides for MHC class I is a predictor of survival in advanced lung cancer and melanoma

scientific article
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

scientific article
Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome

scientific article published on 2 March 2015
Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters

scientific article published in October 2017
Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer.

scientific article
Cyclin D mediates tolerance of genome-doubling in cancers with functional p53.

scientific article
Computational optimisation of targeted DNA sequencing for cancer detection.

scientific article published on 3 December 2013
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

scientific article published on 07 October 2019
Cancer Evolution Constrained by the Immune Microenvironment

scientific article published in August 2017
Neoantigen quality, not quantity

scientific article published on 01 August 2019
A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables

scientific article published on July 2011
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

scientific article published on 05 March 2020
Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

scientific article published in Nature
A clonal expression biomarker associates with lung cancer mortality

scientific article published on 07 October 2019

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