List of works - William E. Klunk

Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34.

scientific article

Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial.

scientific article

Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B

scientific article published on July 2008

Development of positron emission tomography β-amyloid plaque imaging agents

scientific article

Amyloid burden and neural function in people at risk for Alzheimer's Disease

scientific article

Amyloid imaging as a biomarker for cerebral β-amyloidosis and risk prediction for Alzheimer dementia

scientific article published on December 2011

In vivo fibrillar beta-amyloid detected using [11C]PiB positron emission tomography and neuropathologic assessment in older adults

scientific article

In vivo assessment of amyloid-β deposition in nondemented very elderly subjects

scientific article

Alteration of a clinically meaningful outcome in the natural history of Alzheimer's disease by cholinesterase inhibition.

scientific article published in January 2005

PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET.

scientific article published on 21 February 2008

Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease

scientific article

Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe

scientific article published in July 1995

Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease

scientific article published on 14 August 2006

Development of small molecule probes for the Beta-amyloid protein of Alzheimer's Disease

article

Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study

scientific article

Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B.

scientific article

Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease

scientific article published in January 1995

Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements

scientific article published on 17 February 2009

Classification of amyloid-positivity in controls: comparison of visual read and quantitative approaches.

scientific article

Arterial stiffness and β-amyloid progression in nondemented elderly adults.

scientific article

The long-term effects of conventional and atypical antipsychotics in patients with probable Alzheimer's disease

scientific article

Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques

scientific article published on 5 August 2012

Clinical severity of Alzheimer's disease is associated with PIB uptake in PET.

scientific article

Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease

scientific article

Cognitive functioning in relation to brain amyloid-β in healthy adults with Down syndrome

scientific article published on July 2, 2014

The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease

scientific article

Impact of amyloid imaging on drug development in Alzheimer's disease

scientific article

Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B.

scientific article published on 16 May 2008

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia

scientific article published on 29 November 2017

Psychosis in Alzheimer disease: postmortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology.

scientific article

Analysis of magnetic resonance spectra by mole percent: comparison to absolute units

scientific article published in January 1994

Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia

scientific article

2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease

scientific article

Longitudinal assessment of neuroimaging and clinical markers in autosomal dominant Alzheimer's disease: a prospective cohort study

scientific article published on June 29, 2015

Quantitative 1H and 31P MRS of PCA extracts of postmortem Alzheimer's disease brain

scientific article published in May 1996

Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern?

scientific article published on 14 August 2008

Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment.

scientific article published in January 2003

Psychotic symptoms in Alzheimer's disease are not associated with more severe neuropathologic features

scientific article published in December 2000

Phosphocreatine-dependent Glutamate Uptake by Synaptic Vesicles

scientific article published in Journal of Biological Chemistry

Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease.

scientific article

Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells

scientific article published in January 1998

The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferation

scientific article published on December 2008

Inter-rater reliability of manual and automated region-of-interest delineation for PiB PET.

scientific article

Update on amyloid imaging: from healthy aging to Alzheimer's disease

scientific article published on September 2009

X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease

scientific article published on January 2006

Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles

scientific article published in December 2001

Imaging technology for neurodegenerative diseases: progress toward detection of specific pathologies

scientific article

Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography

scientific article published on November 2003

Amyloid-β Imaging in Older Adults Presenting to a Memory Clinic with Subjective Cognitive Decline: A Pilot Study

scientific article published on September 24, 2015

Biological Markers of Alzheimer’s Disease

scientific article published on March 1, 1998

List of works by William E. Klunk

Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34.

Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial.

Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B

Development of positron emission tomography β-amyloid plaque imaging agents

Amyloid burden and neural function in people at risk for Alzheimer's Disease

Amyloid imaging as a biomarker for cerebral β-amyloidosis and risk prediction for Alzheimer dementia

In vivo fibrillar beta-amyloid detected using [11C]PiB positron emission tomography and neuropathologic assessment in older adults

In vivo assessment of amyloid-β deposition in nondemented very elderly subjects

Alteration of a clinically meaningful outcome in the natural history of Alzheimer's disease by cholinesterase inhibition.

PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET.

Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease

Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe

Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease

Development of small molecule probes for the Beta-amyloid protein of Alzheimer's Disease

Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study

Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B.

Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease

Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements

Classification of amyloid-positivity in controls: comparison of visual read and quantitative approaches.

Arterial stiffness and β-amyloid progression in nondemented elderly adults.

The long-term effects of conventional and atypical antipsychotics in patients with probable Alzheimer's disease

Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques

Clinical severity of Alzheimer's disease is associated with PIB uptake in PET.

Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease

Cognitive functioning in relation to brain amyloid-β in healthy adults with Down syndrome

The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease

Impact of amyloid imaging on drug development in Alzheimer's disease

Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B.

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia

Psychosis in Alzheimer disease: postmortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology.

Analysis of magnetic resonance spectra by mole percent: comparison to absolute units

Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia

2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease

Longitudinal assessment of neuroimaging and clinical markers in autosomal dominant Alzheimer's disease: a prospective cohort study

Quantitative 1H and 31P MRS of PCA extracts of postmortem Alzheimer's disease brain

Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern?

Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment.

Psychotic symptoms in Alzheimer's disease are not associated with more severe neuropathologic features

Phosphocreatine-dependent Glutamate Uptake by Synaptic Vesicles

Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease.

Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells

The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferation

Inter-rater reliability of manual and automated region-of-interest delineation for PiB PET.

Update on amyloid imaging: from healthy aging to Alzheimer's disease

X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease

Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles

Imaging technology for neurodegenerative diseases: progress toward detection of specific pathologies

Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography

Amyloid-β Imaging in Older Adults Presenting to a Memory Clinic with Subjective Cognitive Decline: A Pilot Study

Biological Markers of Alzheimer’s Disease