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List of works by Pieter Leyssen

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The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase

scientific article published on February 2005
Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein

scientific article
Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri

scientific article published on 29 August 2012
Molecular strategies to inhibit the replication of RNA viruses

scientific article published on 04 February 2008
Trigocherrin A, the first natural chlorinated daphnane diterpene orthoester from Trigonostemon cherrieri

scientific article published on 19 December 2011
Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

scientific article
Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development

scientific article published on July 2009
A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.

scientific article published on 29 July 2013
Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C.

scientific article
Efficacy of cidofovir in a murine model of disseminated progressive vaccinia

scientific article
The anti-yellow fever virus activity of ribavirin is independent of error-prone replication

scientific article
Interferons, Interferon Inducers, and Interferon-Ribavirin in Treatment of Flavivirus-Induced Encephalitis in Mice

scientific article
α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

scientific article published on 24 February 2020
3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

scientific article
Complete genome sequence, taxonomic assignment, and comparative analysis of the untranslated regions of the Modoc virus, a flavivirus with no known vector

scientific article published on February 2002
Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus

scientific article
Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation.

scientific article published on 2 March 2018
Complete genome sequence of Montana Myotis leukoencephalitis virus, phylogenetic analysis and comparative study of the 3' untranslated region of flaviviruses with no known vector

scientific article published in August 2002
The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication

scientific article
Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replication

scientific article published on 7 December 2012
Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivo

scientific article published on 06 May 2013
A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase

scientific article
Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata

scientific article published on 6 May 2015
Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C.

scientific article published on 18 January 2013
The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family

scientific article
Towards the design of combination therapy for the treatment of enterovirus infections

scientific article published on 3 April 2011
Discovery of a novel HCV helicase inhibitor by a de novo drug design approach

scientific article
Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors

scientific article published on 16 October 2010
Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family

scientific article published on 7 March 2011
Flacourtosides A-F, phenolic glycosides isolated from Flacourtia ramontchi

scientific article published on 22 March 2012
Coumarin-purine ribofuranoside conjugates as new agents against hepatitis C virus

scientific article
Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors

scientific article (publication date: September 2008)
Acute Encephalitis, a Poliomyelitis-like Syndrome and Neurological Sequelae in a Hamster Model for Flavivirus Infections

scientific article
Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases

scientific article published on 15 June 2015
Exchanging the yellow fever virus envelope proteins with Modoc virus prM and E proteins results in a chimeric virus that is neuroinvasive in SCID mice

scientific article published on July 2004
Anti-enterovirus activity and structure–activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles

scientific article published in 2007
Infection of SCID mice with Montana Myotis leukoencephalitis virus as a model for flavivirus encephalitis

scientific article published on August 2002
Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.

scientific article
Identification of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as novel inhibitors of Chikungunya virus replication

scientific article
Rodent models for the study of therapy against flavivirus infections

scientific article published in August 2004
Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections

scientific article
Chemical constituents of Anacolosa pervilleana and their antiviral activities

scientific article published on 14 May 2012
Structure-activity relationship study of arbidol derivatives as inhibitors of chikungunya virus replication

scientific article
Tigliane diterpenes from Croton mauritianus as inhibitors of chikungunya virus replication

scientific article published on 28 May 2014
Antiviral Activity of Diterpene Esters on Chikungunya Virus and HIV Replication

scientific article published on 13 May 2015
Bioengineering and semisynthesis of an optimized cyclophilin inhibitor for treatment of chronic viral infection

scientific article
Novel 1,2,4-triazole and imidazole derivatives of L-ascorbic and imino-ascorbic acid: synthesis, anti-HCV and antitumor activity evaluations

scientific article published on 15 February 2012
Trigocherrierin A, a potent inhibitor of chikungunya virus replication.

scientific article published on 24 March 2014
Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

scientific article published on 5 April 2017
Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway

scientific article published on 22 February 2016

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