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List of works by Jeffrey Bluestone

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Innate immunity and intestinal microbiota in the development of Type 1 diabetes

scientific article
International trial of the Edmonton protocol for islet transplantation

scientific article
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

scientific article published on 26 July 2009
Natural versus adaptive regulatory T cells

scientific article
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

scientific article published on May 2002
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

scientific article published on March 2008
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes

scientific article
The NOD mouse: a model of immune dysregulation

scientific article
Genetics, pathogenesis and clinical interventions in type 1 diabetes

scientific article
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

scientific article
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

scientific article
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

scientific article published on 22 December 2013
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.

scientific article
Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

scientific article published on October 1, 2003
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity

scientific article
A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

scientific article
Control of TH17 cells occurs in the small intestine.

scientific article
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

scientific article published on September 10, 2012
Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice

scientific article published on 12 August 2007
Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways.

scientific article published on August 2008
TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes

scientific article
Regulatory T cells: recommendations to simplify the nomenclature.

scientific article published in April 2013
Type 1 diabetes immunotherapy using polyclonal regulatory T cells

scientific article published on November 25, 2015
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins.

scientific article
CD3-specific antibodies: a portal to the treatment of autoimmunity

scientific article
Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

scientific article
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

scientific article
Expansion of human regulatory T-cells from patients with type 1 diabetes

scientific article published on 15 December 2008
Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

scientific article published on June 2008
Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function

scientific article published in November 2004
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.

scientific article
A comprehensive review of interventions in the NOD mouse and implications for translation

scientific article
NKG2D blockade prevents autoimmune diabetes in NOD mice

scientific article
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

scientific article
Intrinsic and extrinsic control of peripheral T‐cell tolerance by costimulatory molecules of the CD28/ B7 family

scientific article published on May 1, 2011
Plasticity of CD4(+) FoxP3(+) T cells

scientific article published on 06 June 2009
A resource for the conditional ablation of microRNAs in the mouse.

scientific article
Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

scientific article
Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response

scientific article
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen

scientific article
Cell-based therapeutics: the next pillar of medicine

scientific article published on April 2013
TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs

scientific article published on 15 September 2005
Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

scientific article published on 16 June 2015
Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody

scientific article published in March 2004
Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function

scientific article published on June 20, 2012
Impairment of NK cell function by NKG2D modulation in NOD mice

scientific article published in January 2003
Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease

scientific article published on February 15, 2016
How do CD4+CD25+ regulatory T cells control autoimmunity?

scientific article
Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells

scientific article published on May 2009
The functional plasticity of T cell subsets

scientific article

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