List of works - Patrick G. Holt

Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma

scientific article published on 13 March 2007

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

scientific article

The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development

scientific article published on 9 April 2015

A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells

scientific article published on 01 February 1983

Regulation of immunological homeostasis in the respiratory tract

scientific article published on February 2008

Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study

scientific article published in August 2006

Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells

scientific article published in Science

Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial

scientific article published in December 2003

Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces

scientific article

The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppres

scientific article

Early identification of atopy in the prediction of persistent asthma in children

scientific article published on September 2008

Atopic versus infectious diseases in childhood: a question of balance?

scientific article published in May 1997

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

scientific article

After asthma: redefining airways diseases.

scientific article published on 11 September 2017

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

scientific article

Development of interleukin-12-producing capacity throughout childhood

scientific article

Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells

scientific article

Contemporaneous maturation of immunologic and respiratory functions during early childhood: implications for development of asthma prevention strategies

scientific article

Development of the airway intraepithelial dendritic cell network in the rat from class II major histocompatibility (Ia)-negative precursors: differential regulation of Ia expression at different levels of the respiratory tract.

scientific article published on January 1994

Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor

scientific article

Defence against allergic sensitization in the healthy lung: the role of inhalation tolerance.

scientific article

Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma

scientific article

Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children

scientific article published in August 2002

A potential vaccine strategy for asthma and allied atopic diseases during early childhood.

scientific article published on August 1994

Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype

scientific article

Development of long-term tolerance versus sensitisation to environmental allergens during the perinatal period.

scientific article published on December 1997

Ia-positive dendritic cells form a tightly meshed network within the human airway epithelium

scientific article published on 01 November 1989

Maternal smoking in pregnancy alters neonatal cytokine responses

article

Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children

scientific article

Postnatal Development of Monocyte Cytokine Responses to Bacterial Lipopolysaccharide

article

Allergic respiratory disease: strategic targets for primary prevention during childhood.

scientific article published in January 1997

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

scientific article published on 22 December 2017

Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages

scientific article

Th2-associated local reactions to the acellular diphtheria-tetanus-pertussis vaccine in 4- to 6-year-old children

scientific article

Airways Inflammation, Atopy, and (1 → 3)- β -d-Glucan Exposures in Two Schools

scientific article published on 01 November 1998

Maternal fish oil supplementation in pregnancy reduces interleukin-13 levels in cord blood of infants at high risk of atopy

scientific article published on 01 April 2003

Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition.

scientific article published in March 2004

Inhalant allergen-specific T-cell reactivity is detectable in close to 100% of atopic and normal individuals: covert responses are unmasked by serum-free medium

article

Immunoprophylaxis of atopy: light at the end of the tunnel?

scientific article published on 01 October 1994

Alveolar macrophages. I. a simple technique for the preparation of high numbers of viable alveolar macrophages from small laboratory animals

scientific article published on January 1, 1979

Regulation of immune response to inhaled antigen by alveolar macrophages: differential effects of in vivo alveolar macrophage elimination on the induction of tolerance vs. immunity

scientific article published in November 1991

Induction of IgE-secreting cells and IgE isotype-specific suppressor T cells in the respiratory lymph nodes of rats in response to antigen inhalation

article

CpG methylation patterns in the IFNgamma promoter in naive T cells: variations during Th1 and Th2 differentiation and between atopics and non-atopics

scientific article published on December 2006

Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop

scientific article

Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort

scientific article published on 6 April 2007

Postnatal maturation of immune competence during infancy and childhood.

scientific article

Meta-analysis identifies seven susceptibility loci involved in the atopic march

scientific article

Regulation of IgE production in pre-sensitized animals: in vivo elimination of alveolar macrophages preferentially increases IgE responses to inhaled allergen*

article

Regulation of T-cell activation in the lung: alveolar macrophages induce reversible T-cell anergy in vitro associated with inhibition of interleukin-2 receptor signal transduction

scientific article published on 01 February 1996

Vitamin D Deficiency at 16 to 20 Weeks’ Gestation Is Associated with Impaired Lung Function and Asthma at 6 Years of Age

scientific article published on 01 May 2014

List of works by Patrick G. Holt

Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development

A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells

Regulation of immunological homeostasis in the respiratory tract

Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study

Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells

Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial

Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces

The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppres

Early identification of atopy in the prediction of persistent asthma in children

Atopic versus infectious diseases in childhood: a question of balance?

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

After asthma: redefining airways diseases.

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Development of interleukin-12-producing capacity throughout childhood

Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells

Contemporaneous maturation of immunologic and respiratory functions during early childhood: implications for development of asthma prevention strategies

Development of the airway intraepithelial dendritic cell network in the rat from class II major histocompatibility (Ia)-negative precursors: differential regulation of Ia expression at different levels of the respiratory tract.

Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor

Defence against allergic sensitization in the healthy lung: the role of inhalation tolerance.

Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma

Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children

A potential vaccine strategy for asthma and allied atopic diseases during early childhood.

Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype

Development of long-term tolerance versus sensitisation to environmental allergens during the perinatal period.

Ia-positive dendritic cells form a tightly meshed network within the human airway epithelium

Maternal smoking in pregnancy alters neonatal cytokine responses

Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children

Postnatal Development of Monocyte Cytokine Responses to Bacterial Lipopolysaccharide

Allergic respiratory disease: strategic targets for primary prevention during childhood.

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages

Th2-associated local reactions to the acellular diphtheria-tetanus-pertussis vaccine in 4- to 6-year-old children

Airways Inflammation, Atopy, and (1 → 3)- β -d-Glucan Exposures in Two Schools

Maternal fish oil supplementation in pregnancy reduces interleukin-13 levels in cord blood of infants at high risk of atopy

Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition.

Inhalant allergen-specific T-cell reactivity is detectable in close to 100% of atopic and normal individuals: covert responses are unmasked by serum-free medium

Immunoprophylaxis of atopy: light at the end of the tunnel?

Alveolar macrophages. I. a simple technique for the preparation of high numbers of viable alveolar macrophages from small laboratory animals

Regulation of immune response to inhaled antigen by alveolar macrophages: differential effects of in vivo alveolar macrophage elimination on the induction of tolerance vs. immunity

Induction of IgE-secreting cells and IgE isotype-specific suppressor T cells in the respiratory lymph nodes of rats in response to antigen inhalation

CpG methylation patterns in the IFNgamma promoter in naive T cells: variations during Th1 and Th2 differentiation and between atopics and non-atopics

Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop

Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort

Postnatal maturation of immune competence during infancy and childhood.

Meta-analysis identifies seven susceptibility loci involved in the atopic march

Regulation of IgE production in pre-sensitized animals: in vivo elimination of alveolar macrophages preferentially increases IgE responses to inhaled allergen*

Regulation of T-cell activation in the lung: alveolar macrophages induce reversible T-cell anergy in vitro associated with inhibition of interleukin-2 receptor signal transduction

Vitamin D Deficiency at 16 to 20 Weeks’ Gestation Is Associated with Impaired Lung Function and Asthma at 6 Years of Age