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List of works by Peter Keightley

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Evolution of genes and genomes on the Drosophila phylogeny

scientific article
The distribution of fitness effects of new mutations

scientific article
MULTIFACTORIAL GENETICSUNDERSTANDING QUANTITATIVE GENETIC VARIATION

scientific article
Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila

scientific article
Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size change

scientific article published on 17 June 2009
Analysis of the genome sequences of three Drosophila melanogaster spontaneous mutation accumulation lines

scientific article published on 13 May 2009
Joint inference of the distribution of fitness effects of deleterious mutations and population demography based on nucleotide polymorphism frequencies

scientific article published on December 2007
Interference among deleterious mutations favours sex and recombination in finite populations

scientific article
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.

scientific article
Direct estimation of the mitochondrial DNA mutation rate in Drosophila melanogaster

scientific article
Ubiquitous selective constraints in the Drosophila genome revealed by a genome-wide interspecies comparison

scientific article
Evidence for widespread degradation of gene control regions in hominid genomes

scientific article
Quantifying the Slightly Deleterious Mutation Model of Molecular Evolution

article
Patterns of evolutionary constraints in intronic and intergenic DNA of Drosophila.

scientific article
Rates and Fitness Consequences of New Mutations in Humans

scientific article published on February 1, 2012
Distributions of selectively constrained sites and deleterious mutation rates in the hominid and murid genomes.

scientific article published in January 2010
Evidence for pervasive adaptive protein evolution in wild mice

scientific article
Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents

scientific article
Current hypotheses for the evolution of sex and recombination

scientific article published on June 1, 2012
Toward a realistic model of mutations affecting fitness

scientific article published on March 1, 2003
Intron size and exon evolution in Drosophila

scientific article
Estimation of the spontaneous mutation rate per nucleotide site in a Drosophila melanogaster full-sib family.

scientific article
Contributions of protein-coding and regulatory change to adaptive molecular evolution in murid rodents

scientific article
Estimate of the spontaneous mutation rate in Chlamydomonas reinhardtii

scientific article published on 10 October 2012
Estimation of the spontaneous mutation rate in Heliconius melpomene

scientific article
The scale of mutational variation in the murid genome

scientific article published on 15 July 2005
The effect of variation in the effective population size on the rate of adaptive molecular evolution in eukaryotes.

scientific article
A method for inferring the rate of occurrence and fitness effects of advantageous mutations

scientific article published on 27 September 2011
A comparison of models to infer the distribution of fitness effects of new mutations

scientific article
What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?

scientific article
Genomic selective constraints in murid noncoding DNA

scientific article
Extensive de novo mutation rate variation between individuals and across the genome of Chlamydomonas reinhardtii

scientific article published on August 10, 2015
MCALIGN: stochastic alignment of noncoding DNA sequences based on an evolutionary model of sequence evolution

scientific article published on March 2004
Evolutionary constraints in conserved nongenic sequences of mammals.

scientific article published on October 2005
Spontaneous mutational variation for body size in Caenorhabditis elegans

scientific article
Faster-X adaptive protein evolution in house mice.

scientific article published on 20 December 2013
Regulatory variation at glypican-3 underlies a major growth QTL in mice

scientific article
Inference of Site Frequency Spectra From High-Throughput Sequence Data: Quantification of Selection on Nonsynonymous and Synonymous Sites in Humans

scientific article published on May 19, 2011
Global population divergence and admixture of the brown rat (Rattus norvegicus).

scientific article published in the Proceedings of the Royal Society B in October 2016
Analysis and implications of mutational variation.

scientific article published on 29 July 2008
PAPPA2, an enzyme that cleaves an insulin-like growth-factor-binding protein, is a candidate gene for a quantitative trait locus affecting body size in mice

scientific article
Genetic complexity of an obesity QTL ( Fob3) revealed by detailed genetic mapping

scientific article published on 01 June 2004
Microarray gene expression analysis of the Fob3b obesity QTL identifies positional candidate gene Sqle and perturbed cholesterol and glycolysis pathways

scientific article published on 14 December 2004
Estimating the rate of adaptive molecular evolution when the evolutionary divergence between species is small

scientific article
The role of advantageous mutations in enhancing the evolution of a recombination modifier

scientific article published on 5 February 2010
A resolution of the mutation load paradox in humans

scientific article
Positive and negative selection on noncoding DNA close to protein-coding genes in wild house mice.

scientific article published on 8 November 2010
The Nature of Genetic Variation for Complex Traits Revealed by GWAS and Regional Heritability Mapping Analyses

scientific article published on 19 October 2015
Spontaneous mutation accumulation in multiple strains of the green alga, Chlamydomonas reinhardtii

scientific article published on July 9, 2014
Fine mapping of a murine growth locus to a 1.4-cM region and resolution of linked QTL

scientific article published on 01 June 2004

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