List of works - Michael Wakelam

Update of the LIPID MAPS comprehensive classification system for lipids

scientific article

Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism

article

Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development

scientific article published on July 2006

Shorthand notation for lipid structures derived from mass spectrometry.

scientific article

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

scientific article

Phospholipase D

scientific article

Activation of two signal-transduction systems in hepatocytes by glucagon

scientific article published in Nature

Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation

scientific article published on 25 September 2014

Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

scientific article

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

scientific article

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.

scientific article

Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase.

scientific article published on October 1995

Identification of serum biomarkers for colon cancer by proteomic analysis

scientific article published on 6 June 2006

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.

scientific article published on 23 January 2013

PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

scientific article

Diacylglycerol--when is it an intracellular messenger?

scientific article

Transmitter-like action of ATP on patched membranes of cultured myoblasts and myotubes

scientific article published in Nature

Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration.

scientific article published on January 2012

The role of protein kinase C in the induction of nitric oxide synthesis by murine macrophages.

scientific article published on November 1992

A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein

scientific article

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.

scientific article

TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid

scientific article (publication date: 2 August 2002)

Breast cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A(2) and 5-lipoxygenase catalyzed pathway

scientific article (publication date: 22 August 2002)

Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

scientific article published on 28 March 2017

The regulation of phospholipase D by inositol phospholipids and small GTPases

scientific article

Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells

scientific article

Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells

scientific article published on 2 June 2005

Phosphatidylinositol 3′-Kinase-independent p70 S6 Kinase Activation by Fibroblast Growth Factor Receptor-1 Is Important for Proliferation but Not Differentiation of Endothelial Cells

scientific article published on September 12, 1997

Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity.

scientific article published on 27 October 2006

Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells

scientific journal article

Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion

scientific article published on 01 February 2007

Activation of the G(i) heterotrimeric G protein by ANCA IgG F(ab')2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG.

scientific article published in March 2003

C13orf31 (FAMIN) is a central regulator of immunometabolic function

scientific journal article

Phospholipase D1b and D2a generate structurally identical phosphatidic acid species in mammalian cells

scientific article published on December 15, 2001

Elevated serum matrix metalloproteinase 9 (MMP-9) concentration predicts the presence of colorectal neoplasia in symptomatic patients.

scientific article published on 2 October 2007

Analysis of intact phosphoinositides in biological samples

scientific article published on 21 April 2006

Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels.

scientific article published on April 2009

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal

scientific article (publication date: October 2014)

Fast targeted multidimensional NMR metabolomics of colorectal cancer

scientific article published on 01 December 2009

lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction.

scientific article published in February 2006

LipidHome: a database of theoretical lipids optimized for high throughput mass spectrometry lipidomics

scientific article published on 7 May 2013

Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells

scientific article published on 27 October 2003

Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Igamma b

scientific journal article

Proteomic profiling of urine for the detection of colon cancer.

scientific article published on 16 June 2008

Deciphering lipid structures based on platform-independent decision rules.

scientific article

Inter-regulatory dynamics of phospholipase D and the actin cytoskeleton.

scientific article published on 05 May 2009

Activation of phospholipase D and phosphatidylinositol 4-phosphate 5-kinase in HL60 membranes is mediated by endogenous Arf but not Rho

scientific article published on 01 July 1996

Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fcgamma receptors and CD18.

scientific article published in March 2004

Acute manipulation of diacylglycerol reveals roles in nuclear envelope assembly & endoplasmic reticulum morphology

scientific article

Diacylglycerol kinase epsilon, but not zeta, selectively removes polyunsaturated diacylglycerol, inducing altered protein kinase C distribution in vivo.

scientific article published on December 1999

List of works by Michael Wakelam

Update of the LIPID MAPS comprehensive classification system for lipids

Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism

Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development

Shorthand notation for lipid structures derived from mass spectrometry.

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

Phospholipase D

Activation of two signal-transduction systems in hepatocytes by glucagon

Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation

Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.

Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase.

Identification of serum biomarkers for colon cancer by proteomic analysis

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.

PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

Diacylglycerol--when is it an intracellular messenger?

Transmitter-like action of ATP on patched membranes of cultured myoblasts and myotubes

Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration.

The role of protein kinase C in the induction of nitric oxide synthesis by murine macrophages.

A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.

TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid

Breast cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A(2) and 5-lipoxygenase catalyzed pathway

Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

The regulation of phospholipase D by inositol phospholipids and small GTPases

Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells

Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells

Phosphatidylinositol 3′-Kinase-independent p70 S6 Kinase Activation by Fibroblast Growth Factor Receptor-1 Is Important for Proliferation but Not Differentiation of Endothelial Cells

Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity.

Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells

Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion

Activation of the G(i) heterotrimeric G protein by ANCA IgG F(ab')2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG.

C13orf31 (FAMIN) is a central regulator of immunometabolic function

Phospholipase D1b and D2a generate structurally identical phosphatidic acid species in mammalian cells

Elevated serum matrix metalloproteinase 9 (MMP-9) concentration predicts the presence of colorectal neoplasia in symptomatic patients.

Analysis of intact phosphoinositides in biological samples

Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels.

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal

Fast targeted multidimensional NMR metabolomics of colorectal cancer

lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction.

LipidHome: a database of theoretical lipids optimized for high throughput mass spectrometry lipidomics

Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells

Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Igamma b

Proteomic profiling of urine for the detection of colon cancer.

Deciphering lipid structures based on platform-independent decision rules.

Inter-regulatory dynamics of phospholipase D and the actin cytoskeleton.

Activation of phospholipase D and phosphatidylinositol 4-phosphate 5-kinase in HL60 membranes is mediated by endogenous Arf but not Rho

Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fcgamma receptors and CD18.

Acute manipulation of diacylglycerol reveals roles in nuclear envelope assembly & endoplasmic reticulum morphology

Diacylglycerol kinase epsilon, but not zeta, selectively removes polyunsaturated diacylglycerol, inducing altered protein kinase C distribution in vivo.