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List of works by Atsushi Ohtsu

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Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

scientific article
Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial

scientific article (publication date: October 2014)
Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study

scientific article (publication date: 20 October 2011)
Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study

scientific article published on 7 October 2009
Randomized Trial of TAS-102 for Refractory Metastatic Colorectal Cancer

scientific article published on May 14, 2015
Everolimus for previously treated advanced gastric cancer: results of the randomized, double-blind, phase III GRANITE-1 study

scientific article published on 16 September 2013
Randomized phase III trial of fluorouracil alone versus fluorouracil plus cisplatin versus uracil and tegafur plus mitomycin in patients with unresectable, advanced gastric cancer: The Japan Clinical Oncology Group Study (JCOG9205).

scientific article published on January 2003
Lapatinib Plus Paclitaxel Versus Paclitaxel Alone in the Second-Line Treatment of HER2-Amplified Advanced Gastric Cancer in Asian Populations: TyTAN—A Randomized, Phase III Study

scientific article published on May 27, 2014
Safety and Efficacy of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric and Gastroesophageal Junction Cancer: Phase 2 Clinical KEYNOTE-059 Trial

scientific article
Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a biomarker evaluation from the AVAGAST randomized phase III trial

scientific article published on 07 May 2012
Long-term toxicity after definitive chemoradiotherapy for squamous cell carcinoma of the thoracic esophagus

scientific article
Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial

scientific article published on 04 June 2018
Squamous cell carcinoma in situ at oropharyngeal and hypopharyngeal mucosal sites

scientific article published in September 2004
Phase II Study of Chemoradiotherapy With 5-Fluorouracil and Cisplatin for Stage II–III Esophageal Squamous Cell Carcinoma: JCOG Trial (JCOG 9906)

scientific article published on October 6, 2010
TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial

scientific article published on 28 August 2012
Multicenter Phase II Study of Everolimus in Patients With Previously Treated Metastatic Gastric Cancer

scientific article published on March 15, 2010
UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer

scientific article
Comparison of HER2 gene amplification assessed by fluorescence in situ hybridization and HER2 protein expression assessed by immunohistochemistry in gastric cancer.

scientific article
Esophageal stenosis after endoscopic mucosal resection of superficial esophageal lesions

scientific article published on 01 February 2003
Chemotherapy for metastatic gastric cancer: past, present, and future

scientific article published on 06 May 2008
Disparities in gastric cancer chemotherapy between the East and West

scientific article
Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28

scientific article published on 01 July 2007
Nivolumab treatment for oesophageal squamous-cell carcinoma: an open-label, multicentre, phase 2 trial

scientific article published on 14 March 2017
Association of multiple Lugol-voiding lesions with synchronous and metachronous esophageal squamous cell carcinoma in patients with head and neck cancer

scientific article published in October 2002
Expression profiles of HER2, EGFR, MET and FGFR2 in a large cohort of patients with gastric adenocarcinoma

scientific article published on March 14, 2014
Vandetanib in patients with previously treated RET-rearranged advanced non-small-cell lung cancer (LURET): an open-label, multicentre phase 2 trial

scientific article published on 4 November 2016
Nonrandomized comparison between definitive chemoradiotherapy and radical surgery in patients with T(2-3)N(any) M(0) squamous cell carcinoma of the esophagus

scientific article published in October 2003
A new technique for endoscopic mucosal resection with an insulated-tip electrosurgical knife improves the completeness of resection of intramucosal gastric neoplasms

scientific article published on 01 April 2002
Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan

scientific article published on December 2003
Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population.

scientific article published in January 2004
Phase II study of oral S-1 for treatment of metastatic colorectal carcinoma

scientific article published in June 2004
Efficacy of preventive endoscopic balloon dilation for esophageal stricture after endoscopic resection

scientific article published in March 2011
Pharmacodynamic Studies of Gefitinib in Tumor Biopsy Specimens From Patients With Advanced Gastric Carcinoma

scientific article published on 01 September 2006
Phase I Study of NK012, a Novel SN-38–Incorporating Micellar Nanoparticle, in Adult Patients with Solid Tumors

scientific article published on October 13, 2010
Trastuzumab emtansine versus taxane use for previously treated HER2-positive locally advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma (GATSBY): an international randomised, open-label, adaptive, phase 2/3 study

scientific article
Clinicopathological features of programmed death ligand 1 expression with tumor-infiltrating lymphocyte, mismatch repair, and Epstein-Barr virus status in a large cohort of gastric cancer patients

scientific article published on 14 September 2016
mTOR as a therapeutic target in patients with gastric cancer

scientific article published on 05 October 2011
Prognostic impact of HER2, EGFR, and c-MET status on overall survival of advanced gastric cancer patients

scientific article published on February 15, 2015
Gastric Cancer Working Group Report

scientific article published on September 1, 2010
The IDEA (International Duration Evaluation of Adjuvant Chemotherapy) Collaboration: Prospective Combined Analysis of Phase III Trials Investigating Duration of Adjuvant Therapy with the FOLFOX (FOLFOX4 or Modified FOLFOX6) or XELOX (3 versus 6 [...]

scientific article (publication date: 2013)
Risk of multiple squamous cell carcinomas both in the esophagus and the head and neck region

scientific article
Clinical impact of criteria for complete response (CR) of primary site to treatment of esophageal cancer

scientific article published on 16 June 2005
Local recurrence of squamous-cell carcinoma of the esophagus after EMR

scientific article published on 01 February 2005
Phase I clinical and pharmacokinetic study of RAD001 (everolimus) administered daily to Japanese patients with advanced solid tumors

scientific article
Long-term survival and prognostic factors in patients with metastatic gastric cancers treated with chemotherapy in the Japan Clinical Oncology Group (JCOG) study

scientific article published in November 2004
Efficacy of trastuzumab in Japanese patients with HER2-positive advanced gastric or gastroesophageal junction cancer: a subgroup analysis of the Trastuzumab for Gastric Cancer (ToGA) study

scientific article published on December 17, 2011
Phase 2 study of nilotinib as third-line therapy for patients with gastrointestinal stromal tumor

scientific article
Randomized Phase III Study of 5-Fluorouracil Continuous Infusion vs. Sequential Methotrexate and 5-Fluorouracil Therapy in Far Advanced Gastric Cancer with Peritoneal Metastasis (JCOG0106)

scientific article published on September 7, 2013
A retrospective study of definitive chemoradiotherapy for elderly patients with esophageal cancer

scientific article
Phase I dose‐escalation study of buparlisib (BKM120), an oral pan‐class I PI3K inhibitor, in Japanese patients with advanced solid tumors

scientific article published on February 13, 2014

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